SynthesisEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2018
Pepsin in saliva as a diagnostic biomarker in laryngopharyngeal reflux: a meta-analysis.
Synthesis in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- ACG Clinical Guidelines: Clinical Use of Esophageal Physiologic Testing.The American journal of gastroenterology · 2020Guideline
- Pepsin in Saliva as a Diagnostic Marker for Gastroesophageal Reflux Disease: A Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2018Pooled it
- Diagnostic utility of salivary pepsin in laryngopharyngeal reflux: a systematic review and meta-analysis.Brazilian journal of otorhinolaryngologyPooled it
- Influence of proton pump inhibitor therapy on occurrence of voice prosthesis complications.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2020Trial
- Inverse correlation between acid reflux and dwell time of voice protheses (ProvoxEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Global research trends and knowledge gaps in chronic pharyngitis: A bibliometric analysis (2007-2025).European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Review
- Laryngopharyngeal reflux current developments and therapeutic strategies.BMC gastroenterology · 2026Review
- Diagnostic and Management Approach to Reflux-Related Cough.Gastroenterology & hepatology · 2026Article
- Salivary Metabolite Variation After High-Intensity Rowing Training and Potential Biomarker Screening for Exercise-Induced Muscle Damage.Metabolites · 2025Article
- Incidence of and Risk Factors for Laryngopharyngeal Reflux in Patients Undergoing Modified Electroconvulsive Therapy: A Prospective Observational Study.Therapeutics and clinical risk management · 2025Article
- Salivary pH testing in Laryngopharyngeal Reflux Disease.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024Article
- Pathophysiology of gastro-oesophageal reflux disease: implications for diagnosis and management.Nature reviews. Gastroenterology & hepatology · 2024Review
- Latin American consensus on diagnosis of gastroesophageal reflux disease.Neurogastroenterology and motility · 2024Article
- Review article: Diagnosis and management of laryngopharyngeal reflux.Alimentary pharmacology & therapeutics · 2024Review
- Elevated Saliva Pepsin Concentration as a Risk Factor for Asthma in Children with Allergic Rhinitis: A Preliminary Study.Journal of asthma and allergy · 2024Article
- Salivary pepsin as an independent predictor of treatment response for laryngopharyngeal reflux: prospective cohort study with multivariate analysis.Scientific reports · 2023Article
- Laryngopharyngeal Reflux Scoring in a Pediatric Population.Journal of clinical medicine · 2023Article
- Saliva pepsin measurements in the detection of gastroesophageal reflux disease in laryngopharyngeal reflux patients: a cohort study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023Article
- A Novel Salivary Sensor with Integrated Au Electrodes and Conductivity Meters for Screening of Diabetes.Biosensors · 2023Article
- Promising applications of human-derived saliva biomarker testing in clinical diagnostics.International journal of oral science · 2023Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectivePepsin in saliva has been proposed as a biomarker for the diagnosis of laryngopharyngeal reflux (LPR), but the results remain controversial. We assessed the diagnostic value of pepsin in saliva for LPR.
methodsPubMed, Embase, and Web of Science were searched for studies in English that evaluated the utility of pepsin in saliva in the diagnosis of LPR, published up to 15 March 2017. We used Stata 12.0 to summarize the diagnostic indexes for the meta-analysis.
resultsEleven eligible studies met the inclusion criteria. After the meta-analysis of included studies, the pooled sensitivity and specificity were 64% [95% confidence interval (CI) 43-80%] and 68% (95% CI 55-78%), respectively; the positive (PLR) and negative (NLR) likelihood ratios were 2.0 (95% CI 1.4-2.9) and 0.54 (95% CI 0.33-0.87), respectively; the diagnostic odds ratio (DOR) was 4 (95% CI 2-8); and the area under the curve (AUC) was 0.71 (95% CI 0.67-0.75).
conclusionPepsin in saliva has moderate value in the diagnosis of LPR. The cutoff value used could affect the diagnostic value. Therefore, further investigations are required to find the optimal method to detect salivary pepsin in diagnosing LPR.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.