Evidence map›Paper›PMID 29238867›Full record

ArticleEuropean radiology2018

A direct comparison of contrast-enhanced ultrasound and dynamic contrast-enhanced magnetic resonance imaging for prostate cancer detection and prediction of aggressiveness.

Alexander D J Baur, Julia Schwabe, Julian Rogasch, Andreas Maxeiner, Tobias Penzkofer, Carsten Stephan, Marc Rudl, Bernd Hamm, Ernst-Michael Jung, Thom Fischer

Abstract readComparative StudyVideo-Audio Media
PubMed Publisher
In one paragraph

Article in European radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Observational
  8. Article
  9. Review
  10. Aptamer-conjugated multi-walled carbon nanotubes as a new targeted ultrasound contrast agent for the diagnosis of prostate cancer.Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology · 2018
    Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Alexander D J BaurCharité - Universitätsmedizin Berlin, Campus Virchow-Klinikum, Klinik für Strahlenheilkunde, Augustenburger Platz 1, 13353, Berlin, Germany. alexander.baur@charite.de.
Julia SchwabeCharité - Universitätsmedizin Berlin, Campus Charité Mitte, Institut für Radiologie, Berlin, Germany.
Julian RogaschCharité - Universitätsmedizin Berlin, Campus Virchow-Klinikum, Klinik für Nuklearmedizin, Berlin, Germany.
Andreas MaxeinerCharité - Universitätsmedizin Berlin, Campus Charité Mitte, Klinik für Urologie, Berlin, Germany.
Tobias PenzkoferCharité - Universitätsmedizin Berlin, Campus Virchow-Klinikum, Klinik für Strahlenheilkunde, Augustenburger Platz 1, 13353, Berlin, Germany.
Carsten StephanCharité - Universitätsmedizin Berlin, Campus Charité Mitte, Klinik für Urologie, Berlin, Germany.
Marc RudlBerliner Forschungsinstitut für Urologie, Berlin, Germany.
Bernd HammCharité - Universitätsmedizin Berlin, Campus Virchow-Klinikum, Klinik für Strahlenheilkunde, Augustenburger Platz 1, 13353, Berlin, Germany.
Ernst-Michael JungUniversitätsklinikum Regensburg, Institut für Röntgendiagnostik, Regensburg, Germany.
Thom FischerCharité - Universitätsmedizin Berlin, Campus Charité Mitte, Institut für Radiologie, Berlin, Germany.
Charité - Universitätsmedizin Berlin · DEUniversity Hospital Regensburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) and contrast-enhanced ultrasound (CEUS) analyse tissue vascularization. We evaluated if CEUS can provide comparable information as DCE-MRI for the detection of prostate cancer (PCa) and prediction of its aggressiveness. MATERIAL AND

methodsA post-hoc evaluation of 92 patients was performed. In each patient CEUS and DCE-MRI parameters of the most suspicious lesion identified on MRI were analysed. The predictive values for discrimination between benign lesions, low-/intermediate- and high-grade PCa were evaluated. Results of targeted biopsy served as reference standard (benign lesions, n=51; low- and intermediate-grade PCa [Gleason grade group 1 and 2], n=22; high-grade PCa [≥ Gleason grade group 3], n=19).

resultsIn peripheral zone lesions of all tested CEUS parameters only time to peak (TTP

conclusionDCE-MRI showed a superior performance for detection of PCa and prediction of its aggressiveness. CEUS and DCE-MRI performed better in peripheral zone lesions than in transition zone lesions. KEY POINTS: • DCE-MRI gathers information about vascularization and capillary permeability characteristics of tissues. • DCE-MRI can detect PCa and predict its aggressiveness. • CEUS also gathers information about vascularization of tissues. • For detection of PCa and prediction of aggressiveness DCE-MRI performed superiorly. • Both imaging techniques performed better in peripheral zone lesions.

Indexed as

EndosonographyNeoplasm GradingAdultAgedAged, 80 and overContrast MediaHumansImage-Guided BiopsyMagnetic Resonance ImagingMaleMiddle AgedNeoplasm InvasivenessPredictive Value of TestsProstateProstatic NeoplasmsRectumContrast MediaContrast mediaDetectionMagnetic resonance imagingProstate cancerTransrectal ultrasound

Identifiers

PMID29238867
OpenAlexW2775389258

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.