ArticleChromosoma2018
Spatial organization of chromosome territories in the interphase nucleus of trisomy 21 cells.
Article in Chromosoma, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed.
- Computational histology reveals that concomitant application of insect repellent with sunscreen impairs UV protection in an ex vivo human skin model.Parasites & vectors · 2025Article
- The effect of trisomic chromosomes on spatial genome organization and global transcription in embryonic stem cells.Cell proliferation · 2024Article
- Trisomies Reorganize Human 3D Genome.International journal of molecular sciences · 2023Article
- Dissection of a Down syndrome-associated trisomy to separate the gene dosage-dependent and -independent effects of an extra chromosome.Human molecular genetics · 2023Article
- Article
- NODeJ: an ImageJ plugin for 3D segmentation of nuclear objects.BMC bioinformatics · 2022Article
- Review
- Effects of aneuploidy on cell behaviour and function.Nature reviews. Molecular cell biology · 2022Review
- Chromosome length and gene density contribute to micronuclear membrane stability.Life science alliance · 2022Article
- Article
- Three-dimensional chromatin organization in cardiac development and disease.Journal of molecular and cellular cardiology · 2021Review
- Nuclear Reorganization in Hippocampal Granule Cell Neurons from a Mouse Model of Down Syndrome: Changes in Chromatin Configuration, Nucleoli and Cajal Bodies.International journal of molecular sciences · 2021Article
- Shaping of the 3D genome by the ATPase machine cohesin.Experimental & molecular medicine · 2020Review
- Automated 3D bio-imaging analysis of nuclear organization by NucleusJ 2.0.Nucleus (Austin, Tex.) · 2020Article
- Down syndrome.Nature reviews. Disease primers · 2020Review
- Radial Organization in the Mammalian Nucleus.Frontiers in genetics · 2020Review
- Blank spots on the map: some current questions on nuclear organization and genome architecture.Histochemistry and cell biology · 2018Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the interphase cell nucleus, chromosomes adopt a conserved and non-random arrangement in subnuclear domains called chromosome territories (CTs). Whereas chromosome translocation can affect CT organization in tumor cell nuclei, little is known about how aneuploidies can impact CT organization. Here, we performed 3D-FISH on control and trisomic 21 nuclei to track the patterning of chromosome territories, focusing on the radial distribution of trisomic HSA21 as well as 11 disomic chromosomes. We have established an experimental design based on cultured chorionic villus cells which keep their original mesenchymal features including a characteristic ellipsoid nuclear morphology and a radial CT distribution that correlates with chromosome size. Our study suggests that in trisomy 21 nuclei, the extra HSA21 induces a shift of HSA1 and HSA3 CTs out toward a more peripheral position in nuclear space and a higher compaction of HSA1 and HSA17 CTs. We posit that the presence of a supernumerary chromosome 21 alters chromosome compaction and results in displacement of other chromosome territories from their usual nuclear position.
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Registered trials
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