Evidence map›Paper›PMID 29238595›Full record

ArticleJournal of materials chemistry. C2015

Electrochemical processes and mechanistic aspects of field-effect sensors for biomolecules.

Weiguo Huang, Abdou Karim Diallo, Jennifer L Dailey, Kalpana Besar, Howard E Katz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of materials chemistry. C, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Weiguo HuangDepartment of Materials Science and Engineering, Johns Hopkins University, 3400 North Charles Street, 206 Maryland Hall, Baltimore, MD, USA.
Abdou Karim DialloDepartment of Materials Science and Engineering, Johns Hopkins University, 3400 North Charles Street, 206 Maryland Hall, Baltimore, MD, USA.
Jennifer L DaileyDepartment of Materials Science and Engineering, Johns Hopkins University, 3400 North Charles Street, 206 Maryland Hall, Baltimore, MD, USA.
Kalpana BesarDepartment of Materials Science and Engineering, Johns Hopkins University, 3400 North Charles Street, 206 Maryland Hall, Baltimore, MD, USA.
Howard E KatzDepartment of Materials Science and Engineering, Johns Hopkins University, 3400 North Charles Street, 206 Maryland Hall, Baltimore, MD, USA.

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
NCATS NIH HHS UL1 TR001079
6 · The paper itself

Abstract

Electronic biosensing is a leading technology for determining concentrations of biomolecules. In some cases, the presence of an analyte molecule induces a measured change in current flow, while in other cases, a new potential difference is established. In the particular case of a field effect biosensor, the potential difference is monitored as a change in conductance elsewhere in the device, such as across a film of an underlying semiconductor. Often, the mechanisms that lead to these responses are not specifically determined. Because improved understanding of these mechanisms will lead to improved performance, it is important to highlight those studies where various mechanistic possibilities are investigated. This review explores a range of possible mechanistic contributions to field-effect biosensor signals. First, we define the field-effect biosensor and the chemical interactions that lead to the field effect, followed by a section on theoretical and mechanistic background. We then discuss materials used in field-effect biosensors and approaches to improving signals from field-effect biosensors. We specifically cover the biomolecule interactions that produce local electric fields, structures and processes at interfaces between bioanalyte solutions and electronic materials, semiconductors used in biochemical sensors, dielectric layers used in top-gated sensors, and mechanisms for converting the surface voltage change to higher signal/noise outputs in circuits.

Identifiers

PMID29238595
PMCPMC5724786

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.