Evidence map›Paper›PMID 29238589›Full record

ArticleUnited European gastroenterology journal2017

Cannabidiol restores intestinal barrier dysfunction and inhibits the apoptotic process induced by

Stefano Gigli, Luisa Seguella, Marcella Pesce, Eugenia Bruzzese, Alessandra D'Alessandro, Rosario Cuomo, Luca Steardo, Giovanni Sarnelli, Giuseppe Esposito

Open access · bronzeAbstract read
In one paragraph

Article in United European gastroenterology journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 41 citations in OpenAlex.

  1. Trial
  2. Efficacy of Cannabidiol in Reducing Virulence ofInternational journal of molecular sciences · 2026
    Article
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  16. Article
  17. Frontiers in antibiotic alternatives forWorld journal of gastroenterology · 2021
    Article
  18. Applications ofFoods (Basel, Switzerland) · 2021
    Article
  19. Cannabinoids and Inflammations of the Gut-Lung-Skin Barrier.Journal of personalized medicine · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Stefano GigliDepartment of Physiology and Pharmacology, La Sapienza University of Rome, Rome, Italy.
Luisa SeguellaDepartment of Physiology and Pharmacology, La Sapienza University of Rome, Rome, Italy.
Marcella PesceDepartment of Clinical Medicine and Surgery, University of Naples 'Federico II', Naples, Italy.
Eugenia BruzzeseDepartment of Translational Medical Science, University of Naples 'Federico II', Naples, Italy.
Alessandra D'AlessandroDepartment of Clinical Medicine and Surgery, University of Naples 'Federico II', Naples, Italy.
Rosario CuomoDepartment of Clinical Medicine and Surgery, University of Naples 'Federico II', Naples, Italy.
Luca SteardoDepartment of Physiology and Pharmacology, La Sapienza University of Rome, Rome, Italy.
Giovanni SarnelliDepartment of Clinical Medicine and Surgery, University of Naples 'Federico II', Naples, Italy.
Giuseppe EspositoDepartment of Physiology and Pharmacology, La Sapienza University of Rome, Rome, Italy.
University of Naples Federico II · ITSapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background

objectiveThe purpose of this study was to evaluate (a) the anti-apoptotic effect and (b) the mechanisms by which cannabidiol protects mucosal integrity in Caco-2 cells exposed to

methodsCaco-2 cells were exposed to

results

conclusionsCannabidiol improved

Indexed as

cannabidiolcannabinoidsClostridium difficileclostridium difficile toxin Aintestinal permeability

Identifiers

PMID29238589
PMCPMC5721977
OpenAlexW2595451311

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.