Evidence map›Paper›PMID 29238081›Full record

ArticleCell death & disease2017

Pyridoxine 5'-phosphate oxidase is a novel therapeutic target and regulated by the TGF-β signalling pathway in epithelial ovarian cancer.

Lingyun Zhang, Daibing Zhou, Wencai Guan, Weimin Ren, Wenwen Sun, Jimin Shi, Qunbo Lin, Jinguo Zhang, Tiankui Qiao, Yulong Ye and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 77 citations in OpenAlex.

  1. Article
  2. Review
  3. From Fly to Human: Translational Relevance ofInternational journal of molecular sciences · 2026
    Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. RBM15‑mediating MDR1 mRNA mInternational journal of oncology · 2023
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Lingyun ZhangCenter Laboratory, Jinshan Hospital, Fudan University, Shanghai, 201508, China.
Daibing ZhouCenter Laboratory, Jinshan Hospital, Fudan University, Shanghai, 201508, China.
Wencai GuanCenter Laboratory, Jinshan Hospital, Fudan University, Shanghai, 201508, China.
Weimin RenCenter Laboratory, Jinshan Hospital, Fudan University, Shanghai, 201508, China.
Wenwen SunCenter Laboratory, Jinshan Hospital, Fudan University, Shanghai, 201508, China.
Jimin ShiCenter Laboratory, Jinshan Hospital, Fudan University, Shanghai, 201508, China.
Qunbo LinCenter Laboratory, Jinshan Hospital, Fudan University, Shanghai, 201508, China.
Jinguo ZhangCenter Laboratory, Jinshan Hospital, Fudan University, Shanghai, 201508, China.
Tiankui QiaoDepartment of Oncology, Jinshan Hospital, Fudan University, Shanghai, 201508, China.
Yulong YeShanghai Jinshan District Center for Disease Control and Prevention, Shanghai, 201599, China.
Yun WuShanghai Jinshan District Center for Disease Control and Prevention, Shanghai, 201599, China.
Yaning ZhangShanghai Jinshan District Center for Disease Control and Prevention, Shanghai, 201599, China.
Xulei ZuoDepartment of Obstetrics and Gynecology, Jinshan Hospital, Fudan University, Shanghai, 201508, China.
Kristin L ConnorDepartment of Health Sciences, Carleton University, Ottawa, ON, K1S 5B6, Canada.
Guoxiong XuCenter Laboratory, Jinshan Hospital, Fudan University, Shanghai, 201508, China. guoxiong.xu@fudan.edu.cn.
Jinshan Hospital of Fudan University · CNShanghai Municipal Center For Disease Control Prevention · CNShanghai Medical College of Fudan University · CNCarleton University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pyridoxine 5'-phosphate oxidase (PNPO) is an enzyme that converts pyridoxine 5'-phosphate into pyridoxal 5'-phosphate (PLP), an active form of vitamin B6 implicated in several types of cancer. However, the role of PNPO and its regulatory mechanism in epithelial ovarian cancer (EOC) are unknown. In the present study, PNPO expression in human ovarian tumour tissue and its association with the clinicopathological features of patients with EOC were examined. Further, the biological function of PNPO in EOC cells and in xenograft was evaluated. We demonstrated for the first time that PNPO was overexpressed in human EOC. Knockdown of PNPO induced EOC cell apoptosis, arrested cell cycle at G2/M phase, decreased cell proliferation, migration and invasion. Xenografts of PNPO-shRNA-expressing cells into the nude mouse attenuated tumour growth. PNPO at mRNA and protein levels in EOC cells was decreased after transforming growth factor-β1 (TGF-β1) treatment. The inhibitory effect of TGF-β1 on PNPO expression was abolished in the presence of SB-431542, a TGF-β type I receptor kinase inhibitor. Moreover, we found that TGF-β1-mediated PNPO expression was at least in part through the upregulation of miR-143-3p. These data indicate a mechanism underlying PNPO regulation by the TGF-β signalling pathway. Furthermore, PLP administration reduced PNPO expression and decreased EOC cell proliferation, suggesting a feedback loop between PLP and PNPO. Thus, our findings reveal that PNPO can serve as a novel tissue biomarker of EOC and may be a potential target for therapeutic intervention.

Indexed as

Gene Expression Regulation, NeoplasticAnimalsAntagomirsBase SequenceBenzamidesCarcinoma, Ovarian EpithelialCell Line, TumorCell MovementCell ProliferationDioxolesFemaleG2 Phase Cell Cycle CheckpointsHumansMiceMice, NudeMicroRNAs4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamideAntagomirsBenzamidesDioxolesMicroRNAsMIRN143 microRNA, humanProtein Serine-Threonine KinasesPyridoxal PhosphatePyridoxaminephosphate Oxidasepyridoxine 5-phosphateReceptors, Transforming Growth Factor betaReceptor, Transforming Growth Factor-beta Type IRNA, Small InterferingTransforming Growth Factor beta1

Identifiers

PMID29238081
PMCPMC5870590
OpenAlexW2772434918

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.