Evidence map›Paper›PMID 29238043›Full record

ArticleCell death & disease2017

BCL-X

Daniela Trisciuoglio, Maria Grazia Tupone, Marianna Desideri, Marta Di Martile, Chiara Gabellini, Simonetta Buglioni, Matteo Pallocca, Gabriele Alessandrini, Simona D'Aguanno, Donatella Del Bufalo

Open access · goldAbstract read
In one paragraph

Article in Cell death & disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 1 synthesis or guideline pooled it, 112 citations in OpenAlex.

  1. Prognostic Value of Bcl-xL in Head and Neck Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2026
    Pooled it
  2. Article
  3. Review
  4. BCL-2 and BCL-xL in Cancer: Regulation, Function, and Therapeutic Targeting.International journal of molecular sciences · 2026
    Review
  5. Review
  6. Article
  7. Mitochondrial bioenergetics and networks in melanoma: an update.Apoptosis : an international journal on programmed cell death · 2025
    Review
  8. Article
  9. Article
  10. Cell signaling inFrontiers in cellular and infection microbiology · 2025
    Review
  11. Article
  12. Article
  13. Virus nanotechnology for intratumoural immunotherapy.Nature reviews bioengineering · 2024
    Article
  14. Article
  15. Article
  16. Bcl-2 dependent modulation of Hippo pathway in cancer cells.Cell communication and signaling : CCS · 2024
    Article
  17. Materials today. Bio · 2024
    Article
  18. Article
  19. Article
  20. Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Daniela TrisciuoglioPreclinical Models and New Therapeutic Agents Unit, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144, Rome, Italy.ORCID http://orcid.org/0000-0002-7007-7914
Maria Grazia TuponePreclinical Models and New Therapeutic Agents Unit, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144, Rome, Italy.
Marianna DesideriPreclinical Models and New Therapeutic Agents Unit, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144, Rome, Italy.
Marta Di MartilePreclinical Models and New Therapeutic Agents Unit, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144, Rome, Italy.
Chiara GabelliniPreclinical Models and New Therapeutic Agents Unit, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144, Rome, Italy.ORCID http://orcid.org/0000-0002-5544-1570
Simonetta BuglioniPathology Unit, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144, Rome, Italy.
Matteo PalloccaSAFU Unit, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144, Rome, Italy.
Gabriele AlessandriniThoracic Surgery Unit, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144, Rome, Italy.
Simona D'AguannoPreclinical Models and New Therapeutic Agents Unit, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144, Rome, Italy. simona.daguanno@ifo.gov.it.
Donatella Del BufaloPreclinical Models and New Therapeutic Agents Unit, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144, Rome, Italy. donatella.delbufalo@ifo.gov.it.
National Cancer Institute · MYNational Research Council · ITUniversity of Pisa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

By using human melanoma and glioblastoma cell lines and their derivative BCL-X

Indexed as

Gene Expression Regulation, NeoplasticAnimalsbcl-X ProteinBrain NeoplasmsCell Line, TumorCell MovementCell ProliferationDisease ProgressionFemaleGlioblastomaHumansHypoxia-Inducible Factor 1, alpha SubunitMelanomaMiceMice, NudeNanog Homeobox ProteinBCL2L1 protein, humanbcl-X ProteinHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitNanog Homeobox ProteinNANOG protein, humanOctamer Transcription Factor-3POU5F1 protein, humanRNA, Small InterferingSOX2 protein, humanSOXB1 Transcription FactorsThiazolidines

Identifiers

PMID29238043
PMCPMC5870591
OpenAlexW2774687487

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.