ArticleJournal of virology2018
Maintenance of AP-2-Dependent Functional Activities of Nef Restricts Pathways of Immune Escape from CD8 T Lymphocyte Responses.
Open access · bronzeAbstract read
In one paragraph
Article in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- AP2: an indispensable host factor in virus infection.Journal of virology · 2026Review
- The apparent interferon resistance of transmitted HIV-1 is possibly a consequence of enhanced replicative fitness.PLoS pathogens · 2022Article
- Substitutions in Nef That Uncouple Tetherin and SERINC5 Antagonism Impair Simian Immunodeficiency Virus Replication in Primary Rhesus Macaque Lymphocytes.Journal of virology · 2022Article
- The Emerging Role of the Serine Incorporator Protein Family in Regulating Viral Infection.Frontiers in cell and developmental biology · 2022Review
- Selective Disruption of SERINC5 Antagonism by Nef Impairs SIV Replication in Primary CD4Journal of virology · 2021Article
- Tetherin downmodulation by SIVmac Nef lost with the H196Q escape variant is restored by an upstream variant.PloS one · 2020Article
- How HIV Nef Proteins Hijack Membrane Traffic To Promote Infection.Journal of virology · 2019Review
- Structural Basis for Tetherin Antagonism as a Barrier to Zoonotic Lentiviral Transmission.Cell host & microbe · 2019Article
- Lovastatin Inhibits HIV-1-Induced MHC-I Downregulation by Targeting Nef-AP-1 Complex Formation: A New Strategy to Boost Immune Eradication of HIV-1 Infected Cells.Frontiers in immunology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 1 country.
Blake Schouest *Division of Microbiology, Tulane National Primate Research Center, Covington, Louisiana, USA.
Andrea M Weiler *Wisconsin National Primate Research Center, Madison, Wisconsin, USA.
Sanath Kumar JanakaDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Tereance A MyersDivision of Microbiology, Tulane National Primate Research Center, Covington, Louisiana, USA.
Arpita DasDivision of Microbiology, Tulane National Primate Research Center, Covington, Louisiana, USA.
Sarah C WilderDivision of Microbiology, Tulane National Primate Research Center, Covington, Louisiana, USA.
Jessica FurlottWisconsin National Primate Research Center, Madison, Wisconsin, USA.
Melody BaddooTulane Cancer Center, New Orleans, Louisiana, USA.
Erik K FlemingtonTulane Cancer Center, New Orleans, Louisiana, USA.
Eva G RakaszWisconsin National Primate Research Center, Madison, Wisconsin, USA.
David T EvansWisconsin National Primate Research Center, Madison, Wisconsin, USA.
Thomas C FriedrichWisconsin National Primate Research Center, Madison, Wisconsin, USA.
Nicholas J ManessDivision of Microbiology, Tulane National Primate Research Center, Covington, Louisiana, USA nmaness@tulane.edu.
Tulane University · USUniversity of Wisconsin–Madison · USLouisiana Cancer Research Center · US
Funding
WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7MTulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4MNonhuman Primate Reagent ResourceU24AI126683 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Diogo Magnani · 2016 to 2026
$20.1M"Project 3" MHV68 IncRNA/miRNA interaction in latency and lympomagenesisP01CA214091 · NCI · UNIVERSITY OF FLORIDA · PI ERIK K FLEMINGTON · 2017 to 2026
$15.9MSustained antibody delivery for durable suppression of immunodeficiency virus replicationR01AI121135 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI David T Evans · 2015 to 2026
$6.9MKIR and MHC Class I Immunogenetics in SIV InfectionR01AI095098 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI EVANS, DAVID T · 2012 to 2016
$2.7MLentiviral Resistance to TetherinR01AI098485 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI EVANS, DAVID T · 2012 to 2016
$2.2MEpstein Barr virus antisense transcriptionR01AI106676 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI FLEMINGTON, ERIK K · 2014 to 2018
$1.9MSIV antisense epitopes as novel markers of latencyR21AI112447 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI MANESS, NICHOLAS JAMES · 2015 to 2016
$465kNCI NIH HHS P01 CA214091NIAID NIH HHS R01 AI095098NIAID NIH HHS R01 AI098485NIAID NIH HHS R01 AI106676NIAID NIH HHS R01 AI121135NIAID NIH HHS R21 AI112447NIAID NIH HHS U24 AI126683NIH HHS P51 OD011104NIH HHS P51 OD011106
Abstract
Nef-specific CD8
Indexed as
AnimalsBiological EvolutionBone Marrow Stromal Antigen 2CD8-Positive T-LymphocytesEpitopes, T-LymphocyteHistocompatibility Antigens Class IHumansImmune EvasionMacacaMembrane GlycoproteinsMembrane ProteinsMutationnef Gene Products, Human Immunodeficiency VirusNeoplasm ProteinsReceptors, Cell SurfaceRNA, ViralBone Marrow Stromal Antigen 2Epitopes, T-LymphocyteHistocompatibility Antigens Class IMamu-B 01 antigen, Macaca mulattaMembrane GlycoproteinsMembrane Proteinsnef Gene Products, Human Immunodeficiency VirusNEF protein, SIVNeoplasm ProteinsReceptors, Cell SurfaceRNA, ViralSERINC3 protein, humanSERINC5 protein, humanViral Envelope ProteinsViral Regulatory and Accessory ProteinsCD4evolutionmajor histocompatibility complexSERINCsimian immunodeficiency virusTetherinviral escape
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.