Evidence map›Paper›PMID 29237830›Full record

ArticleJournal of virology2018

Axl Can Serve as Entry Factor for Lassa Virus Depending on the Functional Glycosylation of Dystroglycan.

Chiara Fedeli, Giulia Torriani, Clara Galan-Navarro, Marie-Laurence Moraz, Hector Moreno, Gisa Gerold, Stefan Kunz

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Strategies of rational and structure-driven vaccine design for Arenaviruses.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2024
    Review
  11. Article
  12. Article
  13. Article
  14. Entry inhibitors as arenavirus antivirals.Frontiers in microbiology · 2024
    Review
  15. Review
  16. Article
  17. Article
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Chiara Fedeli *Institute of Microbiology, Lausanne University Hospital, Lausanne, Switzerland.
Giulia Torriani *Institute of Microbiology, Lausanne University Hospital, Lausanne, Switzerland.
Clara Galan-NavarroInstitute of Microbiology, Lausanne University Hospital, Lausanne, Switzerland.
Marie-Laurence MorazInstitute of Microbiology, Lausanne University Hospital, Lausanne, Switzerland.
Hector MorenoInstitute of Microbiology, Lausanne University Hospital, Lausanne, Switzerland.
Gisa GeroldTWINCORE, Center for Experimental and Clinical Infection Research, Institute for Experimental Virology, Hannover, Germany.
Stefan KunzInstitute of Microbiology, Lausanne University Hospital, Lausanne, Switzerland Stefan.Kunz@chuv.ch.
University of Lausanne · CHCenter for Experimental and Clinical Infection Research · DEÉcole Polytechnique Fédérale de Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fatal infection with the highly pathogenic Lassa virus (LASV) is characterized by extensive viral dissemination, indicating broad tissue tropism. The major cellular receptor for LASV is the highly conserved extracellular matrix receptor dystroglycan (DG). Binding of LASV depends on DG's tissue-specific posttranslational modification with the unusual O-linked polysaccharide matriglycan. Interestingly, functional glycosylation of DG does not always correlate with viral tropism observed

Indexed as

Virus AttachmentVirus InternalizationA549 CellsAntiviral AgentsArenaviridae InfectionsAxl Receptor Tyrosine KinaseCell Line, TumorDystroglycansEndosomesGene ExpressionGlycosylationHEK293 CellsHeLa CellsHeparan SulfateHumansLassa virusAntiviral AgentsAxl Receptor Tyrosine KinaseDystroglycansHeparan SulfateLAMP1 protein, humanLysosomal-Associated Membrane Protein 1Lysosomal Membrane ProteinsProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesReceptors, VirusTYRO3 protein, humanattachmentAxldystroglycanentry factorLassa virusmacropinocytosisreceptorviral entry

Identifiers

PMID29237830
PMCPMC5809728
OpenAlexW2775151494

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.