ArticleScience translational medicine2017
Thorase variants are associated with defects in glutamatergic neurotransmission that can be rescued by Perampanel.
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In one paragraph
Article in Science translational medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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0cells of the map it votes in
19citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Lipid bilayer properties govern substrate engagement and extraction by the AAA+ ATPase Msp1.The Journal of biological chemistry · 2025Article
- Article
- miR-361-5p contributes to the pathogenesis of Alzheimer's disease.Scientific reports · 2025Article
- Cryo-EM structure of AAA + ATPase thorase reveals novel helical filament formation.Computational and structural biotechnology journal · 2025Article
- ATAD1 Regulates Neuronal Development and Synapse Formation Through Tuning Mitochondrial Function.International journal of molecular sciences · 2024Article
- The AAA+ protein Msp1 recognizes substrates by a hydrophobic mismatch.bioRxiv : the preprint server for biology · 2024Article
- Genetic Deletion of Thorase Causes Purkinje Cell Loss and Impaired Motor Coordination Behavior.Cells · 2023Article
- ATPase Thorase Deficiency Causes α-Synucleinopathy and Parkinson's Disease-like Behavior.Cells · 2022Article
- AAA + ATPase Thorase inhibits mTOR signaling through the disassembly of the mTOR complex 1.Nature communications · 2022Article
- Conserved structural elements specialize ATAD1 as a membrane protein extraction machine.eLife · 2022Article
- Reconstitution of Msp1 Extraction Activity with Fully Purified Components.Journal of visualized experiments : JoVE · 2021Article
- SARS-CoV-2 Neuronal Invasion and Complications: Potential Mechanisms and Therapeutic Approaches.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Review
- Pharmacological modulation of AMPA receptors rescues specific impairments in social behavior associated with the A350V Iqsec2 mutation.Translational psychiatry · 2021Article
- AMPA Receptor Surface Expression Is Regulated by S-Nitrosylation of Thorase and Transnitrosylation of NSF.Cell reports · 2020Article
- Article
- Structure of the AAA protein Msp1 reveals mechanism of mislocalized membrane protein extraction.eLife · 2020Article
- IQSEC2-Associated Intellectual Disability and Autism.International journal of molecular sciences · 2019Review
- AMPA receptors and their minions: auxiliary proteins in AMPA receptor trafficking.Cellular and molecular life sciences : CMLS · 2019Review
- An IQSEC2 Mutation Associated With Intellectual Disability and Autism Results in Decreased Surface AMPA Receptors.Frontiers in molecular neuroscience · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 3 institutions in 2 countries.
George K E UmanahNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID http://orcid.org/0000-0002-1506-6139
Marco PignatelliIntramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA.
Xiling YinNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID http://orcid.org/0000-0002-3942-8210
Rong ChenNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Joshua CrawfordDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Stewart NeifertNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID http://orcid.org/0000-0001-5389-347X
Leslie ScarffeNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID http://orcid.org/0000-0002-3478-7812
Adam A BehenskyNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID http://orcid.org/0000-0003-0984-6013
Noah GuibersonNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID http://orcid.org/0000-0002-7602-5402
Melissa ChangSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Erica MaSchool of Public Health, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID http://orcid.org/0000-0003-1466-4126
Jin Wan KimDepartment of Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID http://orcid.org/0000-0003-2478-1975
Cibele C CastroNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID http://orcid.org/0000-0001-5183-4054
Xiaobo MaoNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID http://orcid.org/0000-0001-6587-556X
Li ChenNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Shaida A AndrabiNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID http://orcid.org/0000-0002-3305-2638
Mikhail V PletnikovDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Ann E PulverDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID http://orcid.org/0000-0002-5929-9161
Dimitrios AvramopoulosDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID http://orcid.org/0000-0003-1492-9104
Antonello BonciIntramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA.
David ValleMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID http://orcid.org/0000-0002-6560-4281
Ted M DawsonNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. vdawson@jhmi.edu tdawson@jhmi.edu.ORCID http://orcid.org/0000-0002-6459-0893
Valina L DawsonNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. vdawson@jhmi.edu tdawson@jhmi.edu.ORCID http://orcid.org/0000-0002-2915-3970
Johns Hopkins University · USNational Institute on Drug Abuse · USUniversidade Federal do Rio Grande do Sul · BR
Funding
UNDERSTANDING NO SIGNALING RESULTING IN NEUROPROTECTION.P50DA000266 · NIDA · JOHNS HOPKINS UNIVERSITY · PI WORLEY, PAUL F · 1985 to 2017
$45.2MProject 3P50MH094268 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SAWA, AKIRA · 2011 to 2020
$19.9MMutant DISC 1 and Abnormal Neurodevelopment in Mental IllnessR01MH083728 · NIMH · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI PLETNIKOV, MIKHAIL V · 2009 to 2020
$4.9MNIDA NIH HHS P50 DA000266NIMH NIH HHS P50 MH094268NIMH NIH HHS R01 MH083728
Abstract
The AAA+ adenosine triphosphatase (ATPase) Thorase plays a critical role in controlling synaptic plasticity by regulating the expression of surface α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs). Bidirectional sequencing of exons of
Indexed as
Genetic VariationAdenosine TriphosphatasesAnimalsATPases Associated with Diverse Cellular ActivitiesBehavior, AnimalCells, CulturedCerebral CortexEndocytosisExcitatory Postsynaptic PotentialsGlutamatesHeterozygoteHumansMemoryMiceNeuronsNitrilesAdenosine TriphosphatasesATPases Associated with Diverse Cellular ActivitiesGlutamatesNitrilesperampanelPyridones
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.