Evidence map›Paper›PMID 29237744›Full record

Observational studyCirculation. Cardiovascular quality and outcomes2017

Change in Cognitive Function in the Month After Hospitalization for Acute Coronary Syndromes: Findings From TRACE-CORE (Transition, Risks, and Actions in Coronary Events-Center for Outcomes Research and Education).

Jane S Saczynski, David D McManus, Molly E Waring, Darleen Lessard, Milena D Anatchkova, Jerry H Gurwitz, Jeroan Allison, Arlene S Ash, Richard H McManus, David C Parish and 2 more

Registry-linked trialAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Circulation. Cardiovascular quality and outcomes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04278911 (Effect of Cognitive Impairment), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04278911 unknown statusnot on this mapstarted 2020, after this paper: background citation

Effect of Cognitive Impairment (CI) on Prognosis in the Elderly Patients With Acute Coronary Syndrome (ACS)

TypeobservationalSponsorBeijing Friendship HospitalRan2020 to 2022Enrolled500ConditionsAcute Coronary Syndrome, Cognitive Impairment, ElderlyArmsMMSE and MoCA
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. A Systematic Approach to Treating Early Metabolic Disease and Prediabetes.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2023
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jane S SaczynskiFrom the Department of Pharmacy and Health System Sciences, Northeastern University, Boston, MA (J.S.S.); Department of Medicine (D.D.M., J.H.G.) and Department of Quantitative Health Sciences (D.D.M., M.E.W., D.L., M.D.A., J.A., A.S.A., R.H.M., R.J.G., C.I.K.), University of Massachusetts Medical School, Worcester; Evidera, Lexington, MA (M.D.A.); Meyers Primary Care Institute, Worcester, MA (J.H.G.); and Department of Medicine, Mercer School of Medicine, Macon, GA (D.C.P.). j.saczynski@northeastern.edu.
David D McManusFrom the Department of Pharmacy and Health System Sciences, Northeastern University, Boston, MA (J.S.S.); Department of Medicine (D.D.M., J.H.G.) and Department of Quantitative Health Sciences (D.D.M., M.E.W., D.L., M.D.A., J.A., A.S.A., R.H.M., R.J.G., C.I.K.), University of Massachusetts Medical School, Worcester; Evidera, Lexington, MA (M.D.A.); Meyers Primary Care Institute, Worcester, MA (J.H.G.); and Department of Medicine, Mercer School of Medicine, Macon, GA (D.C.P.).
Molly E WaringFrom the Department of Pharmacy and Health System Sciences, Northeastern University, Boston, MA (J.S.S.); Department of Medicine (D.D.M., J.H.G.) and Department of Quantitative Health Sciences (D.D.M., M.E.W., D.L., M.D.A., J.A., A.S.A., R.H.M., R.J.G., C.I.K.), University of Massachusetts Medical School, Worcester; Evidera, Lexington, MA (M.D.A.); Meyers Primary Care Institute, Worcester, MA (J.H.G.); and Department of Medicine, Mercer School of Medicine, Macon, GA (D.C.P.).
Darleen LessardFrom the Department of Pharmacy and Health System Sciences, Northeastern University, Boston, MA (J.S.S.); Department of Medicine (D.D.M., J.H.G.) and Department of Quantitative Health Sciences (D.D.M., M.E.W., D.L., M.D.A., J.A., A.S.A., R.H.M., R.J.G., C.I.K.), University of Massachusetts Medical School, Worcester; Evidera, Lexington, MA (M.D.A.); Meyers Primary Care Institute, Worcester, MA (J.H.G.); and Department of Medicine, Mercer School of Medicine, Macon, GA (D.C.P.).
Milena D AnatchkovaFrom the Department of Pharmacy and Health System Sciences, Northeastern University, Boston, MA (J.S.S.); Department of Medicine (D.D.M., J.H.G.) and Department of Quantitative Health Sciences (D.D.M., M.E.W., D.L., M.D.A., J.A., A.S.A., R.H.M., R.J.G., C.I.K.), University of Massachusetts Medical School, Worcester; Evidera, Lexington, MA (M.D.A.); Meyers Primary Care Institute, Worcester, MA (J.H.G.); and Department of Medicine, Mercer School of Medicine, Macon, GA (D.C.P.).
Jerry H GurwitzFrom the Department of Pharmacy and Health System Sciences, Northeastern University, Boston, MA (J.S.S.); Department of Medicine (D.D.M., J.H.G.) and Department of Quantitative Health Sciences (D.D.M., M.E.W., D.L., M.D.A., J.A., A.S.A., R.H.M., R.J.G., C.I.K.), University of Massachusetts Medical School, Worcester; Evidera, Lexington, MA (M.D.A.); Meyers Primary Care Institute, Worcester, MA (J.H.G.); and Department of Medicine, Mercer School of Medicine, Macon, GA (D.C.P.).
Jeroan AllisonFrom the Department of Pharmacy and Health System Sciences, Northeastern University, Boston, MA (J.S.S.); Department of Medicine (D.D.M., J.H.G.) and Department of Quantitative Health Sciences (D.D.M., M.E.W., D.L., M.D.A., J.A., A.S.A., R.H.M., R.J.G., C.I.K.), University of Massachusetts Medical School, Worcester; Evidera, Lexington, MA (M.D.A.); Meyers Primary Care Institute, Worcester, MA (J.H.G.); and Department of Medicine, Mercer School of Medicine, Macon, GA (D.C.P.).
Arlene S AshFrom the Department of Pharmacy and Health System Sciences, Northeastern University, Boston, MA (J.S.S.); Department of Medicine (D.D.M., J.H.G.) and Department of Quantitative Health Sciences (D.D.M., M.E.W., D.L., M.D.A., J.A., A.S.A., R.H.M., R.J.G., C.I.K.), University of Massachusetts Medical School, Worcester; Evidera, Lexington, MA (M.D.A.); Meyers Primary Care Institute, Worcester, MA (J.H.G.); and Department of Medicine, Mercer School of Medicine, Macon, GA (D.C.P.).
Richard H McManusFrom the Department of Pharmacy and Health System Sciences, Northeastern University, Boston, MA (J.S.S.); Department of Medicine (D.D.M., J.H.G.) and Department of Quantitative Health Sciences (D.D.M., M.E.W., D.L., M.D.A., J.A., A.S.A., R.H.M., R.J.G., C.I.K.), University of Massachusetts Medical School, Worcester; Evidera, Lexington, MA (M.D.A.); Meyers Primary Care Institute, Worcester, MA (J.H.G.); and Department of Medicine, Mercer School of Medicine, Macon, GA (D.C.P.).
David C ParishFrom the Department of Pharmacy and Health System Sciences, Northeastern University, Boston, MA (J.S.S.); Department of Medicine (D.D.M., J.H.G.) and Department of Quantitative Health Sciences (D.D.M., M.E.W., D.L., M.D.A., J.A., A.S.A., R.H.M., R.J.G., C.I.K.), University of Massachusetts Medical School, Worcester; Evidera, Lexington, MA (M.D.A.); Meyers Primary Care Institute, Worcester, MA (J.H.G.); and Department of Medicine, Mercer School of Medicine, Macon, GA (D.C.P.).
Robert J GoldbergFrom the Department of Pharmacy and Health System Sciences, Northeastern University, Boston, MA (J.S.S.); Department of Medicine (D.D.M., J.H.G.) and Department of Quantitative Health Sciences (D.D.M., M.E.W., D.L., M.D.A., J.A., A.S.A., R.H.M., R.J.G., C.I.K.), University of Massachusetts Medical School, Worcester; Evidera, Lexington, MA (M.D.A.); Meyers Primary Care Institute, Worcester, MA (J.H.G.); and Department of Medicine, Mercer School of Medicine, Macon, GA (D.C.P.).
Catarina I KiefeFrom the Department of Pharmacy and Health System Sciences, Northeastern University, Boston, MA (J.S.S.); Department of Medicine (D.D.M., J.H.G.) and Department of Quantitative Health Sciences (D.D.M., M.E.W., D.L., M.D.A., J.A., A.S.A., R.H.M., R.J.G., C.I.K.), University of Massachusetts Medical School, Worcester; Evidera, Lexington, MA (M.D.A.); Meyers Primary Care Institute, Worcester, MA (J.H.G.); and Department of Medicine, Mercer School of Medicine, Macon, GA (D.C.P.).

Funding

TRACE-COREU01HL105268 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KIEFE, CATARINA I. · 2010 to 2013
$5.8M
University of Massachusetts Center for Clinical and Translational ScienceKL2TR000160 · NCATS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LUZURIAGA, KATHERINE F · 2012 to 2014
$1.7M
University of Massachusetts Center for Clinical and Translational ScienceKL2RR031981 · NCRR · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SULLIVAN, JOHN LEWIS · 2010 to 2011
$1.2M
Medical Illness & Cognitive Impairment in Older Adults: Heart Failure as a ModelK01AG033643 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SACZYNSKI, JANE STEELE · 2010 to 2014
$628k
Psychosocial Factors and Rehospitalization after Acute Myocardial InfarctionR21HL108187 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SACZYNSKI, JANE STEELE · 2011 to 2012
$452k
NCATS NIH HHS KL2 TR000160NCRR NIH HHS KL2 RR031981NHLBI NIH HHS R21 HL108187NHLBI NIH HHS U01 HL105268NIA NIH HHS K01 AG033643
6 · The paper itself

Abstract

backgroundCognitive function is often impaired during hospitalization, but whether this impairment resolves or persists after discharge is unknown. METHODS AND

resultsWe enrolled (April 2011-May 2013) and interviewed during hospitalization and 1-month post-discharge 1521 nondemented acute coronary syndrome survivors enrolled in TRACE (Transitions, Risks and Actions in Coronary Events). Cognitive function was assessed using the Telephone Interview of Cognitive Status (range: 0-41) at both time points. Patients reported demographic and psychosocial characteristics and medical records were abstracted. Using the Telephone Interview of Cognitive Status cut point of ≤28, we defined 4 groups of cognitive change based on cognitive status during hospitalization and 1 month later: consistently impaired, transiently impaired, newly impaired, and consistently nonimpaired. Characteristics associated with cognitive change categories were examined using multinomial logistic regression. Participants were 67% male, 84% non-Hispanic white, with mean age±SD 62±11 years; 16% (n=237) were cognitively impaired during hospitalization, and 11% (n=174) were impaired 1 month after discharge. Overall, 80% were consistently nonimpaired, 9% transiently impaired, 7% consistently impaired, and 4% newly impaired. Lower education level, minority status, low health literacy and numeracy, and higher severity of disease were independently associated with cognitive impairment during and after hospitalization. Male sex was associated with increased risk of cognitive impairment after hospital discharge.

conclusionsCognitive function changes during the transition from hospital to home after acute coronary syndrome are less favorable for men and those with psychosocial vulnerability. Assessing cognitive status both in hospital and post-discharge is important for detecting patients who could benefit from tailored transitional care including early follow-up and booster discharge instructions.

Indexed as

CognitionHospitalizationAcute Coronary SyndromeAgedCognition DisordersFemaleGeorgiaHumansLogistic ModelsMaleMassachusettsMiddle AgedMultivariate AnalysisOdds RatioRisk FactorsSeverity of Illness Indexcognitioncognitive dysfunctionepidemiologysurvivors

Identifiers

PMID29237744
PMCPMC5837076

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