ArticleThe Journal of biological chemistry2018
Communication between N terminus and loop2 tunes Orai activation.
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Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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0cells of the map it votes in
34citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 49 citations in OpenAlex.
- Mechanistic insights into Orai dynamics during pore opening.Channels (Austin, Tex.) · 2026Review
- Evolutionarily conserved hydrophobicity and sterics in TM3/TM4 balance Orai1 pore opening.Protein science : a publication of the Protein Society · 2026Article
- ORAI CaBiomolecules · 2024Review
- Synthetic Biology Meets CaCells · 2024Review
- Article
- Photocrosslinking-induced CRAC channel-like Orai1 activation independent of STIM1.Nature communications · 2023Article
- CRAC and SK Channels: Their Molecular Mechanisms Associated with Cancer Cell Development.Cancers · 2022Review
- Similarities and Differences between the Orai1 Variants: Orai1α and Orai1β.International journal of molecular sciences · 2022Review
- The Role of Lipids in CRAC Channel Function.Biomolecules · 2022Review
- Highlighting the Multifaceted Role of Orai1 N-Terminal- and Loop Regions for Proper CRAC Channel Functions.Cells · 2022Review
- STIM and Orai Mediated Regulation of Calcium Signaling in Age-Related Diseases.Frontiers in aging · 2022Review
- Orai1 Boosts SK3 Channel Activation.Cancers · 2021Article
- Deciphering Molecular Mechanisms and Intervening in Physiological and Pathophysiological Processes of CaCells · 2021Review
- Alteration of STIM1/Orai1-Mediated SOCE in Skeletal Muscle: Impact in Genetic Muscle Diseases and Beyond.Cells · 2021Review
- Defects in the STIM1 SOARα2 domain affect multiple steps in the CRAC channel activation cascade.Cellular and molecular life sciences : CMLS · 2021Article
- Isoform-Specific Properties of Orai Homologues in Activation, Downstream Signaling, Physiology and Pathophysiology.International journal of molecular sciences · 2021Review
- Engineering of a bona fide light-operated calcium channel.Nature communications · 2021Article
- The Orai Pore Opening Mechanism.International journal of molecular sciences · 2021Review
- Proteins Interacting with STIM1 and Store-Operated CaProgress in molecular and subcellular biology · 2021Review
- Transmembrane Domain 3 (TM3) Governs Orai1 and Orai3 Pore Opening in an Isoform-Specific Manner.Frontiers in cell and developmental biology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 3 institutions in 2 countries.
Marc FahrnerFrom the Institute of Biophysics, Johannes Kepler University of Linz, Gruberstrasse 40, 4020 Linz, Austria, and.
Saurabh K Pandeythe Center for Nanobiology and Structural Biology, Institute of Microbiology, Academy of Sciences of the Czech Republic, 373 33 Nove Hrady, Czech Republic.
Martin MuikFrom the Institute of Biophysics, Johannes Kepler University of Linz, Gruberstrasse 40, 4020 Linz, Austria, and.
Lukas TraxlerFrom the Institute of Biophysics, Johannes Kepler University of Linz, Gruberstrasse 40, 4020 Linz, Austria, and.
Carmen ButoracFrom the Institute of Biophysics, Johannes Kepler University of Linz, Gruberstrasse 40, 4020 Linz, Austria, and.
Michael StadlbauerFrom the Institute of Biophysics, Johannes Kepler University of Linz, Gruberstrasse 40, 4020 Linz, Austria, and.
Vasilina Zayatsthe Center for Nanobiology and Structural Biology, Institute of Microbiology, Academy of Sciences of the Czech Republic, 373 33 Nove Hrady, Czech Republic.
Adéla KrizovaFrom the Institute of Biophysics, Johannes Kepler University of Linz, Gruberstrasse 40, 4020 Linz, Austria, and.
Peter PlenkFrom the Institute of Biophysics, Johannes Kepler University of Linz, Gruberstrasse 40, 4020 Linz, Austria, and.
Irene FrischaufFrom the Institute of Biophysics, Johannes Kepler University of Linz, Gruberstrasse 40, 4020 Linz, Austria, and.
Rainer SchindlFrom the Institute of Biophysics, Johannes Kepler University of Linz, Gruberstrasse 40, 4020 Linz, Austria, and.
Hermann J GruberFrom the Institute of Biophysics, Johannes Kepler University of Linz, Gruberstrasse 40, 4020 Linz, Austria, and.
Peter HinterdorferFrom the Institute of Biophysics, Johannes Kepler University of Linz, Gruberstrasse 40, 4020 Linz, Austria, and.
Rüdiger Ettrichthe Center for Nanobiology and Structural Biology, Institute of Microbiology, Academy of Sciences of the Czech Republic, 373 33 Nove Hrady, Czech Republic.
Christoph RomaninFrom the Institute of Biophysics, Johannes Kepler University of Linz, Gruberstrasse 40, 4020 Linz, Austria, and christoph.romanin@jku.at.
Isabella DerlerFrom the Institute of Biophysics, Johannes Kepler University of Linz, Gruberstrasse 40, 4020 Linz, Austria, and Isabella.derler@jku.at.
Johannes Kepler University of Linz · ATCzech Academy of Sciences, Institute of Microbiology · CZCzech Academy of Sciences · CZ
Funding
Austrian Science Fund FWF P 25210Austrian Science Fund FWF P 27263Austrian Science Fund FWF P 27641Austrian Science Fund FWF P 28123Austrian Science Fund FWF P 28498Austrian Science Fund FWF P 28701Austrian Science Fund FWF P 28872Austrian Science Fund FWF W 1250
Abstract
Ca
Indexed as
Calcium ChannelsHEK293 CellsHumansNeoplasm ProteinsORAI1 ProteinProtein DomainsProtein Structure, SecondaryStromal Interaction Molecule 1Calcium ChannelsNeoplasm ProteinsORAI1 ProteinORAI1 protein, humanOrai3 protein, humanSTIM1 protein, humanStromal Interaction Molecule 1atomic force microscopy (AFM)calcium release-activated calcium channel protein 1 (ORAI1)electrophysiologysignal transductionstromal interaction molecule 1 (STIM1)
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LicenceCC BY
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.