Observational studyCirculation. Cardiovascular genetics2017
Toward Genetics-Driven Early Intervention in Dilated Cardiomyopathy: Design and Implementation of the DCM Precision Medicine Study.
Observational study in Circulation. Cardiovascular genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03037632 (Precision Medicine for Dilated Cardiomyopathy in European and African Ancestry), which is not on this map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Precision Medicine for Dilated Cardiomyopathy in European and African Ancestry
Who cites it
39 citing papers in PubMed, 55 citations in OpenAlex.
- Alcohol Exposure Among Patients With Dilated Cardiomyopathy and Their First-Degree Relatives: The DCM Precision Medicine Study.Circulation. Genomic and precision medicine · 2025Trial
- Rare Variant Genetics and Dilated Cardiomyopathy Severity: The DCM Precision Medicine Study.Circulation · 2023Trial
- Effectiveness of theCirculation · 2023Trial
- Validating an Idiopathic Dilated Cardiomyopathy Diagnosis Using Cardiovascular Magnetic Resonance: The Dilated Cardiomyopathy Precision Medicine Study.Circulation. Heart failure · 2022Trial
- Care Models for the Genetic Evaluation of Dilated Cardiomyopathy at Sites of the DCM Consortium.medRxiv : the preprint server for health sciences · 2026Article
- Evaluation of Women With Peripartum or Dilated Cardiomyopathy and Their First-Degree Relatives: The DCM Precision Medicine Study.Circulation. Genomic and precision medicine · 2026Observational
- Identification of Biomarkers for Right Ventricular Dysfunction in Idiopathic Dilated Cardiomyopathy Via Urinary Proteomics and Machine Learning.Journal of the American Heart Association · 2026Article
- Antecedent Flu-Like Illness and Onset of Idiopathic Dilated Cardiomyopathy: The DCM Precision Medicine Study.Circulation. Heart failure · 2025Article
- Identification of disease-specific pathways and modifiers in phospholamban R14del cardiomyopathy: rationale, design and baseline characteristics of DECIPHER-PLN cohort.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2025Article
- Similar burden of rare genetic variants in ischemic and non-ischemic dilated cardiomyopathy.Frontiers in cardiovascular medicine · 2025Article
- The DCM Project Portal: A direct-to-participant platform of The DCM Research Project.American heart journal plus : cardiology research and practice · 2024Article
- Genetic Architecture of Dilated Cardiomyopathy in Individuals of African and European Ancestry.JAMA · 2023Article
- The DCM Project Portal: A direct-to-participant platform of The DCM Research Project.medRxiv : the preprint server for health sciences · 2023Article
- Screening for Dilated Cardiomyopathy in At-Risk First-Degree Relatives.Journal of the American College of Cardiology · 2023Article
- Genetic Evaluation and Screening in Cardiomyopathies: Opportunities and Challenges for Personalized Medicine.Journal of personalized medicine · 2023Review
- Cardiovascular Magnetic Resonance Imaging in Familial Dilated Cardiomyopathy.Medicina (Kaunas, Lithuania) · 2023Review
- TTR variants in patients with dilated cardiomyopathy: An investigation of the DCM Precision Medicine Study.Genetics in medicine : official journal of the American College of Medical Genetics · 2022Article
- Communal Coping as a Strategy to Enhance Family Engagement in Dilated Cardiomyopathy.Circulation. Genomic and precision medicine · 2022Review
- Article
- Case Report: A novel desmoplakin mutation in a taiwanese woman with familial dilated cardiomyopathy that necessitated heart transplantation.Frontiers in genetics · 2022Article
Corrections and comments
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Authors and funding
6 authors at 20 institutions in 6 countries.
Funding
Abstract
backgroundThe cause of idiopathic dilated cardiomyopathy (DCM) is unknown by definition, but its familial subtype is considered to have a genetic component. We hypothesize that most idiopathic DCM, whether familial or nonfamilial, has a genetic basis, in which case a genetics-driven approach to identifying at-risk family members for clinical screening and early intervention could reduce morbidity and mortality.
methodsOn the basis of this hypothesis, we have launched the National Heart, Lung, and Blood Institute- and National Human Genome Research Institute-funded DCM Precision Medicine Study, which aims to enroll 1300 individuals (600 non-Hispanic African ancestry, 600 non-Hispanic European ancestry, and 100 Hispanic) who meet rigorous clinical criteria for idiopathic DCM along with 2600 of their relatives. Enrolled relatives will undergo clinical cardiovascular screening to identify asymptomatic disease, and all individuals with idiopathic DCM will undergo exome sequencing to identify relevant variants in genes previously implicated in DCM. Results will be returned by genetic counselors 12 to 14 months after enrollment. The data obtained will be used to describe the prevalence of familial DCM among idiopathic DCM cases and the genetic architecture of idiopathic DCM in multiple ethnicity-ancestry groups. We will also conduct a randomized controlled trial to test the effectiveness of
conclusionsWe anticipate that this study will demonstrate that idiopathic DCM has a genetic basis and guide best practices for a genetics-driven approach to early intervention in at-risk relatives. CLINICAL
trial registrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT03037632.
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