Evidence map›Paper›PMID 29237659›Full record

ArticleBMJ case reports2017

Long-term follow-up of hepatitis-associated aplastic anaemia.

Cristina Gonçalves, Sandra Ferreira, Susana Nobre, Isabel Gonçalves

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in BMJ case reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 81% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Cristina GonçalvesUnidade de Transplantação Hepática - PA, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal.
Sandra FerreiraUnidade de Transplantação Hepática - PA, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal.
Susana NobreUnidade de Transplantação Hepática - PA, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal.
Isabel GonçalvesUnidade de Transplantação Hepática - PA, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal.
Hospitais da Universidade de Coimbra · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prognosis of hepatitis-associated aplastic anaemia (HAAA) was improved with haematopoietic stem cell transplantation (HSCT) and immunosuppression, but the long-term outcome remains undefined. Case 1: a girl aged 3 years with acute liver failure (ALF) submitted to orthotopic liver transplantation (OLT) subsequently developed aplastic anaemia and HSCT from a compatible sibling was performed. Post-HSCT, the patient developed post-transplant lymphoproliferative disorder and rituximab was administered with good response. Fifteen years later, both grafts show good outcome. Case 2: a girl aged 10 years submitted to OLT due to ALF, developed pancytopenia 2 months later. Due to the absence of a human leucocyte antigen compatible donor, she was treated with ciclosporin and antithymocyte globulin with very good long-term outcome. These clinical cases suggest that, for patients with HAAA that underwent OLT, aggressive therapy with HSCT or immunosuppression may provide a benign long-term outcome.

Indexed as

Liver Failure, AcuteLiver TransplantationAcyclovirAnemia, AplasticAntiviral AgentsChildChild, PreschoolDiagnosis, DifferentialFemaleFollow-Up StudiesHematopoietic Stem Cell TransplantationHepatitisHumansPostoperative ComplicationsAcyclovirAntiviral Agentshepatitis othermalignant and benign haematologytransplantation

Identifiers

PMID29237659
PMCPMC5728243
OpenAlexW2774510995

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.