Evidence map›Paper›PMID 29237502›Full record

ArticleWorld journal of surgical oncology2017

Initial clinical presentation of single soft tissue metastasis of medullary thyroid carcinoma without primary tumor in the thyroid gland.

Masanori Okamoto, Akira Takazawa, Kaoru Aoki, Yasuo Yoshimura, Hiroyuki Kato, Toshiaki Otsuki, Kazuma Maeno, Tomonobu Koizumi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of surgical oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 76% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Masanori OkamotoDepartment of Orthopaedic Surgery, Shinshu University School of Medicine, 3-1-1, Asahi, Matsumoto, Japan.
Akira TakazawaDepartment of Orthopaedic Surgery, Shinshu University School of Medicine, 3-1-1, Asahi, Matsumoto, Japan.
Kaoru AokiDepartment of Orthopaedic Surgery, Shinshu University School of Medicine, 3-1-1, Asahi, Matsumoto, Japan.
Yasuo YoshimuraDepartment of Orthopaedic Surgery, Shinshu University School of Medicine, 3-1-1, Asahi, Matsumoto, Japan.
Hiroyuki KatoDepartment of Orthopaedic Surgery, Shinshu University School of Medicine, 3-1-1, Asahi, Matsumoto, Japan.
Toshiaki OtsukiDepartment of Laboratory, Shinshu University School of Medicine, 3-1-1, Asahi, Matsumoto, Japan.
Kazuma MaenoDivision of Breast and Endocrine Surgery, Department of Surgery, Shinshu University School of Medicine, 3-1-1, Asahi, Matsumoto, Japan.
Tomonobu KoizumiDepartment of Comprehensive Cancer Therapy, Shinshu University School of Medicine, 3-1-1, Asahi, Matsumoto Nagano, 390-8621, Japan. tomonobu@shinshu-u.ac.jp.
Shinshu University · JPShinshu University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSingle soft tissue metastasis of medullary thyroid carcinoma is extremely rare. In addition, several occult medullary thyroid carcinomas with distant metastasis were reported, but undetectable primary lesion at diagnosis was also extremely rare. CASE PRESENTATION: A 74-year-old man was admitted to our hospital because of a painful nodule in his left buttock for over 1 year. Needle biopsy was performed, and the histological findings revealed adenocarcinoma positive for thyroid transcription factor-1. No evidence of a primary tumor, including the lung and thyroid gland, could be found elsewhere despite detailed examinations, including thyroid echography, chest computed tomography, and fluorodeoxyglucose-positron emission tomography. The soft tissue tumor was resected with a wide margin. Immunohistochemical analysis showed the tumor cells to be positive for cytokeratin-AE1/3, cytokeratin 7, synaptophysin, chromogranin A, calcitonin, and carcinoembryonic antigen, but negative for cytokeratin 20, Napsin A, Pax8, and p40, resulting in a diagnosis of metastasis of medullary thyroid carcinoma.

conclusionInitial presentation with a single metastasis to soft tissue and undetectable primary tumor in the thyroid gland is an extremely rare clinical manifestation in patients with medullary thyroid carcinoma.

Indexed as

AgedBiopsy, NeedleButtocksCarcinoma, NeuroendocrineEndoscopy, Digestive SystemHumansMagnetic Resonance ImagingMalePositron Emission Tomography Computed TomographySoft Tissue NeoplasmsThyroid GlandThyroid NeoplasmsThyroid Nuclear Factor 1UltrasonographyNKX2-1 protein, humanThyroid Nuclear Factor 1CalcitoninCEAPrimary unknown originSoft tissue metastasisTTF-1

Identifiers

PMID29237502
PMCPMC5729399
OpenAlexW2774695770

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.