Evidence map›Paper›PMID 29237495›Full record

ArticleStem cell research & therapy2017

Bone marrow CD34

Shuning Zhang, Xin Ma, Junjie Guo, Kang Yao, Cong Wang, Zhen Dong, Hong Zhu, Fan Fan, Zheyong Huang, Xiangdong Yang and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research & therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Shuning ZhangDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Xin MaInstitute of Cardiovascular Diseases, Fudan University, Shanghai, China.
Junjie GuoDepartment of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao University, Shandong, China.
Kang YaoDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Cong WangDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Zhen DongDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Hong ZhuDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Fan FanDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Zheyong HuangDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Xiangdong YangDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Juying QianDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Yunzeng ZouDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Aijun SunDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China. sun.aijun@zs-hospital.sh.cn.
Junbo GeDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China. jbge@zs-hospital.sh.cn.
Fudan University · CNZhongshan Hospital · CNSun Yat-sen University · CNAffiliated Hospital of Qingdao University · CNThe First Affiliated Hospital, Sun Yat-sen University · CN

Funding

National Natural Science Foundation of China 81100075National Natural Science Foundation of China 81570317Research Fund for the Doctoral Program of Higher Education, China 20100071120074Research Fund of Fudan University, China 20520133376the Youth Science Funds of the Shanghai Municipal Health Bureau, Shanghai, China 2010Y029Youth Science Funds of Zhongshan hospital KB363
6 · The paper itself

Abstract

backgroundThe stiffness of the myocardial extracellular matrix (ECM) and the transplanted cell type are vitally important in promoting angiogenesis. However, the combined effect of the two factors remains uncertain. The purpose of this study is to investigate in vitro the combined effect of myocardial ECM stiffness postinfarction with a bone marrow-derived cell subset expressing or not expressing CD34 on endothelial lineage commitment.

methodsMyocardial stiffness of the infarct zone was determined in mice at 1 h, 24 h, 7 days, 14 days, and 28 days after coronary artery ligation. Polyacrylamide (PA) gel substrates of different stiffnesses were prepared to mechanically mimic the myocardial ECM after infarction. Mouse bone marrow-derived CD34

resultsWe found that the numbers of the CD34

conclusionsInfarcted myocardium-like ECM of moderate stiffness (42 kPa) more beneficially regulated the endothelial lineage commitment of a bone marrow-derived CD34

Indexed as

Acrylic ResinsActinsAnimalsAntigens, CDAntigens, CD34BiomarkersBiomimetic MaterialsBone Marrow CellsCadherin 5CadherinsCell AdhesionCell DifferentiationCoronary VesselsElasticityEndothelial CellsExtracellular MatrixAcrylic ResinsActinsAntigens, CDAntigens, CD34BiomarkersCadherin 5CadherinsPlatelet Endothelial Cell Adhesion Molecule-1PolyacrylamidesVascular Endothelial Growth Factor Receptor-2von Willebrand FactorCD34EndothelialMyocardial ECM stiffnessMyocardial infarction

Identifiers

PMID29237495
PMCPMC5729449
OpenAlexW2773347190

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.