Evidence map›Paper›PMID 29237417›Full record

ArticleBMC nephrology2017

Red cell distribution width associated with adverse cardiovascular outcomes in patients with chronic kidney disease.

Yueh-An Lu, Pei-Chun Fan, Cheng-Chia Lee, Victor Chien-Chia Wu, Ya-Chung Tian, Chih-Wei Yang, Yung-Chang Chen, Chih-Hsiang Chang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC nephrology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yueh-An LuDepartment of Nephrology, Kidney Research Center, Chang Gung Memorial Hospital, Linkou Medical Center, Chang Gung University, No. 5 Fusing Street, Gueishan Dist, Taoyuan City, 333, Taiwan, Republic of China.
Pei-Chun FanDepartment of Nephrology, Kidney Research Center, Chang Gung Memorial Hospital, Linkou Medical Center, Chang Gung University, No. 5 Fusing Street, Gueishan Dist, Taoyuan City, 333, Taiwan, Republic of China.
Cheng-Chia LeeDepartment of Nephrology, Kidney Research Center, Chang Gung Memorial Hospital, Linkou Medical Center, Chang Gung University, No. 5 Fusing Street, Gueishan Dist, Taoyuan City, 333, Taiwan, Republic of China.
Victor Chien-Chia WuGraduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, No.259, Wenhua 1st Rd., Guishan Dist, Taoyuan City, 33302, Taiwan, Republic of China.
Ya-Chung TianDepartment of Nephrology, Kidney Research Center, Chang Gung Memorial Hospital, Linkou Medical Center, Chang Gung University, No. 5 Fusing Street, Gueishan Dist, Taoyuan City, 333, Taiwan, Republic of China.
Chih-Wei YangDepartment of Nephrology, Kidney Research Center, Chang Gung Memorial Hospital, Linkou Medical Center, Chang Gung University, No. 5 Fusing Street, Gueishan Dist, Taoyuan City, 333, Taiwan, Republic of China.
Yung-Chang ChenDepartment of Nephrology, Kidney Research Center, Chang Gung Memorial Hospital, Linkou Medical Center, Chang Gung University, No. 5 Fusing Street, Gueishan Dist, Taoyuan City, 333, Taiwan, Republic of China.
Chih-Hsiang ChangDepartment of Nephrology, Kidney Research Center, Chang Gung Memorial Hospital, Linkou Medical Center, Chang Gung University, No. 5 Fusing Street, Gueishan Dist, Taoyuan City, 333, Taiwan, Republic of China. franwisandsun@gmail.com.ORCID http://orcid.org/0000-0002-7342-335X

Funding

Chang Gung Medical Foundation CMRPG3F1651
6 · The paper itself

Abstract

backgroundRecent studies have demonstrated that red cell distribution width (RDW) is associated with cardiovascular (CV) events and mortality. Patients with chronic kidney disease (CKD) are often anemic and have high RDW levels. In this study, we investigated the effect of RDW on major composite CV outcomes among patients with CKD.

methodsWe retrospectively analyzed patients with CKD who were admitted to the department of cardiology of a tertiary hospital in 2011. The patients were divided into 2 groups: normal RDW (RDW < 14.5%) and elevated RDW (RDW ≥ 14.5%). Demographic characteristics, comorbidities, blood investigation results, prescriptions, and outcomes were analyzed after a 3-year follow-up period. Six adjustment levels were performed to evaluate the effect of RDW on outcomes.

resultsThis study involved 282 patients with CKD: 213 in the elevated RDW group and 69 in the normal RDW group. The elevated RDW group had older patients, a lower proportion of male patients, lower left ventricular ejection fraction (LVEF) values, lower hemoglobin levels, lower serum albumin levels, and higher creatinine levels, compared with the normal RDW group. A linear trend was observed toward higher RDW in patients with deteriorating renal function. In the final adjusted model, RDW ≥ 14.5%, older age, and lower LVEF were associated with an increased risk of major composite CV outcomes.

conclusionRDW is a potentially useful cost-effective indicator of major composite CV outcomes in patients with CKD.

Indexed as

Cardiovascular DiseasesErythrocyte IndicesAgedChinaFemaleHumansMaleMiddle AgedOutcome Assessment, Health CareRenal Insufficiency, ChronicRetrospective StudiesRisk AssessmentRisk FactorsTertiary Care CentersCardiovascular outcomesChronic kidney diseaseRed cell distribution width

Identifiers

PMID29237417
PMCPMC5729452

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.