Evidence map›Paper›PMID 29237415›Full record

ArticleBMC cancer2017

Family history of prostate and colorectal cancer and risk of colorectal cancer in the Women's health initiative.

Jennifer L Beebe-Dimmer, Cecilia Yee, Electra Paskett, Ann G Schwartz, Dorothy Lane, Nynikka R A Palmer, Cathryn H Bock, Rami Nassir, Michael S Simon

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Prostate cancer theragnostics biomarkers: An update.Investigative and clinical urology · 2024
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Jennifer L Beebe-DimmerBarbara Ann Karmanos Cancer Institute, Detroit, Michigan, 48201, USA. dimmerj@karmanos.org.ORCID 0000-0002-4320-739X
Cecilia YeeBarbara Ann Karmanos Cancer Institute, Detroit, Michigan, 48201, USA.
Electra PaskettOhio State University Comprehensive Cancer Center, Columbus, OH, 43210, USA.
Ann G SchwartzBarbara Ann Karmanos Cancer Institute, Detroit, Michigan, 48201, USA.
Dorothy LaneDepartment of Preventive Medicine, Stony Brook University School of Medicine, Stony Brook, New York, 11794, USA.
Nynikka R A PalmerDepartment of Medicine, University of California-San Francisco, San Francisco, California, 94110, USA.
Cathryn H BockBarbara Ann Karmanos Cancer Institute, Detroit, Michigan, 48201, USA.
Rami NassirDepartment of Biochemistry and Molecular Medicine, University of California-Davis, Davis, California, 95616, USA.
Michael S SimonBarbara Ann Karmanos Cancer Institute, Detroit, Michigan, 48201, USA.
Wayne State University · USStony Brook University · USThe Barbara Ann Karmanos Cancer Institute · USThe Ohio State University · USUniversity of California, Davis · USUniversity of California, San Francisco · US

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Jennifer A. Woyach · 1985 to 2026
$132.3M
NCI NIH HHS P30 CA016058NHLBI NIH HHS HHSN2681100002CNHLBI NIH HHS HHSN268201100001CNHLBI NIH HHS HHSN268201100001INHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100003CNHLBI NIH HHS HHSN268201100004CNHLBI NIH HHS HHSN268201100004INHLBI NIH HHS HHSN268201100046CNHLBI NIH HHS HHSN271201100004CNIA NIH HHS HHSN271201100004CWHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004C
6 · The paper itself

Abstract

backgroundEvidence suggests that risk of colorectal and prostate cancer is increased among those with a family history of the same disease, particularly among first-degree relatives. However, the aggregation of colorectal and prostate cancer within families has not been well investigated.

methodsAnalyses were conducted among participants of the Women's Health Initiative (WHI) observational cohort, free of cancer at the baseline examination. Subjects were followed for colorectal cancer through August 31st, 2009. A Cox-proportional hazards regression modeling approach was used to estimate risk of colorectal cancer associated with a family history of prostate cancer, colorectal cancer and both cancers among first-degree relatives of all participants and stratified by race (African American vs. White).

resultsOf 75,999 eligible participants, there were 1122 colorectal cancer cases diagnosed over the study period. A family history of prostate cancer alone was not associated with an increase in colorectal cancer risk after adjustment for confounders (aHR =0.94; 95% CI =0.76, 1.15). Separate analysis examining the joint impact, a family history of both colorectal and prostate cancer was associated with an almost 50% increase in colorectal cancer risk (aHR = 1.48; 95% CI = 1.04, 2.10), but similar to those with a family history of colorectal cancer only (95% CI = 1.31; 95% CI = 1.11, 1.54).

conclusionsOur findings suggest risk of colorectal cancer is increased similarly among women with colorectal cancer only and among those with both colorectal and prostate cancer diagnosed among first-degree family members. Future studies are needed to determine the relative contribution of genes and shared environment to the risk of both cancers.

Indexed as

Medical History TakingAgedAged, 80 and overColorectal NeoplasmsFemaleHumansMaleMiddle AgedProstatic NeoplasmsWomen's Health

Identifiers

PMID29237415
PMCPMC5729427
OpenAlexW2775540559

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.