ReviewCurrent protein & peptide science2018
Viscosity Control of Protein Solution by Small Solutes: A Review.
Review in Current protein & peptide science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 150 citations in OpenAlex.
- Effects of Arginine on Hierarchical Protein Aggregation.The protein journal · 2026Article
- Article
- The viscosity of protein and nucleic acid solutions and their folded structures explored using the free-volume concept and Eyring's rate process theory.RSC advances · 2025Article
- Temperature and excipient mediated modulation of monoclonal antibody interactions revealed bymAbs · 2025Article
- PROPERMAB: an integrative framework formAbs · 2025Article
- Review
- Microemulsion-based formulation of enterocin CC2: a novel antimicrobial solution targeting Streptococcus mutans.Drug delivery and translational research · 2025Article
- Structural and techno-functional properties of pH-shifted protein isolates from unhatched hen eggs.Poultry science · 2025Article
- Matching placebo development for injectable biologics-a practical tutorial.Antibody therapeutics · 2025Article
- Measurement of Aqueous Humor Viscosity in an Experimental Rabbit Model With Corneal Neovascularization.Translational vision science & technology · 2025Article
- Rapid Development of High Concentration Protein Formulation Driven by High-Throughput Technologies.Pharmaceutical research · 2025Article
- Diffusion and Viscosity in Mixed Protein Solutions.The journal of physical chemistry. B · 2024Article
- Article
- Ultrasonic Sensor: A Fast and Non-Destructive System to Measure the Viscosity and Density of Molecular Fluids.Biosensors · 2024Article
- Stability of Protein Pharmaceuticals: Recent Advances.Pharmaceutical research · 2024Review
- EPR Viscometric Measurements Using aApplied magnetic resonance · 2023Article
- Preparation and characterization of soy protein isolate films by pretreatment with cysteine.Food chemistry: X · 2023Article
- Laser-Based Mid-Infrared Spectroscopy for Monitoring Temperature-Induced Denaturation of Bovine Serum Albumin and De-/Stabilization Effects of Sugars.Analytical chemistry · 2023Article
- A comparative high-resolution physicochemical analysis of commercially available fibrin sealants: Impact of sealant osmolality on biological performance.Journal of biomedical materials research. Part A · 2023Article
- Asparagus Fructans as Emerging Prebiotics.Foods (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Viscosity of protein solution is one of the most troublesome issues for the high-concentration formulation of protein drugs. In this review, we summarize the practical methods that suppress the viscosity of protein solution using small molecular additives. The small amount of salts decreases the viscosity that results from electrostatic repulsion and attraction. The chaotrope suppresses the hydrophobic attraction and cluster formation, which can lower the solution viscosity. Arginine hydrochloride (ArgHCl) also suppresses the solution viscosity due to the hydrophobic and aromatic interactions between protein molecules. The small molecular additives are the simplest resolution of the high viscosity of protein solution as well as understanding of the primary cause in complex phenomena of protein interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.