Evidence map›Paper›PMID 29237287›Full record

ArticleAIDS research and human retroviruses2018

Early Sites of Virus Replication After Oral SIV

Angela M Amedee, Bonnie Phillips, Kara Jensen, Spencer Robichaux, Nedra Lacour, Mark Burke, Michael Piatak, Jeffrey D Lifson, Pamela A Kozlowski, Koen K A Van Rompay and 1 more

Open access · greenAbstract read
In one paragraph

Article in AIDS research and human retroviruses, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Pathogenesis of viral infections during pregnancy.Clinical microbiology reviews · 2024
    Review
  7. Review
  8. Nonhuman primate models of pediatric viral diseases.Frontiers in cellular and infection microbiology · 2024
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Angela M Amedee1 Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center , New Orleans, Louisiana.
Bonnie Phillips2 Department of Microbiology and Immunology and Center for AIDS Research, School of Medicine, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina.
Kara Jensen2 Department of Microbiology and Immunology and Center for AIDS Research, School of Medicine, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina.
Spencer Robichaux1 Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center , New Orleans, Louisiana.
Nedra Lacour1 Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center , New Orleans, Louisiana.
Mark Burke3 Howard University , Washington, District of Columbia.
Michael Piatak4 AIDS and Cancer Virus Program, Leidos Biomedical Research, Inc. , Frederick National Laboratory for Cancer Research, Frederick, Maryland.
Jeffrey D Lifson4 AIDS and Cancer Virus Program, Leidos Biomedical Research, Inc. , Frederick National Laboratory for Cancer Research, Frederick, Maryland.
Pamela A Kozlowski1 Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center , New Orleans, Louisiana.
Koen K A Van Rompay5 California National Primate Research Center, University of California , Davis, Davis, California.
Kristina De Paris2 Department of Microbiology and Immunology and Center for AIDS Research, School of Medicine, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina.
Louisiana State University Health Sciences Center New Orleans · USLeidos (United States) · USHoward University · USUniversity of California, Davis · US

Funding

National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5M
Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Optimizing Oral Pediatric HIV Vaccines to Prevent Breast Milk TransmissionR01DE022287 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DE PARIS, KRISTINA · 2012 to 2016
$4.5M
NIAID NIH HHS P30 AI050410NIDCR NIH HHS R01 DE022287NIH HHS P51 OD011107
6 · The paper itself

Abstract

Despite optimization of preventative measures for vertical HIV-1 transmission, daily, roughly 400 infants become HIV infected, most of them through breastfeeding. Viral entry has been presumed to occur in the gastrointestinal tract; however, the exact entry site(s) have not been defined. Therefore, we quantified simian immunodeficiency virus (SIV) RNA and DNA in oral, intestinal, and systemic tissues of 15 infant macaques within 48-96 h after oral SIV

Indexed as

AnimalsAnimals, NewbornBrainDisease Models, AnimalGastrointestinal TractInfectious Disease Transmission, VerticalLungMacaca mulattaMouth MucosaRNA, ViralSimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusViral LoadVirus ReplicationRNA, Viralinfant rhesus macaquesoral SIV infectiontissue distributionvirus replication

Identifiers

PMID29237287
PMCPMC5863100
OpenAlexW2774255497

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.