Evidence map›Paper›PMID 29237149›Full record

ArticleAmerican journal of nephrology2017

Association of Antibodies to Citrullinated Protein Antigens with Blood Pressure in First-Degree Relatives of Rheumatoid Arthritis Patients: The Studies of the Etiology of Rheumatoid Arthritis.

Jan M Hughes-Austin, Ryan W Gan, Kevin D Deane, Michael H Weisman, M Kristen Demoruelle, Jeremy Sokolove, William H Robinson, V Michael Holers, Jill M Norris, Joachim H Ix

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of nephrology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Jan M Hughes-AustinDepartment of Orthopaedic Surgery, School of Medicine, University of California, San Diego, La Jolla, California, USA.
Ryan W GanDepartment of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Kevin D DeaneDepartment of Rheumatology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Michael H WeismanDivision of Rheumatology, Department of Medicine, Cedars-Sinai, Los Angeles, California, USA.
M Kristen DemoruelleDepartment of Rheumatology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Jeremy SokoloveDivision of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.
William H RobinsonDivision of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.
V Michael HolersDepartment of Rheumatology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Jill M NorrisDepartment of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Joachim H IxDivision of Nephrology-Hypertension, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, California, USA.
University of Colorado Anschutz Medical Campus · USColorado School of Public Health · USStanford University · USUniversity of California, San Diego · USCedars-Sinai Medical Center · US

Funding

Virginia Mason/UCHSC Autoimmune Prevention CenterU19AI050864 · NIAID · UNIVERSITY OF COLORADO DENVER · PI HOLERS, VERNON MICHAEL · 2001 to 2011
$29.2M
Research Training in Rheumatology INCLUDE Down Syndrome SupplementT32AR007534 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI Kristine A. Kuhn · 1986 to 2026
$6.1M
RA-Related Autoantibodies in Healthy FDR of RA PatientsR01AR051394 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI NORRIS, JILL M · 2005 to 2011
$3.0M
Antibodies to Citrullinated Protein Antigens, CVD and Bone Disease in MESAK01HL122394 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HUGHES-AUSTIN, JAN MARIE · 2015 to 2019
$836k
Mentored Patient Oriented Research in Kidney DiseaseK24DK110427 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI IX, JOACHIM H · 2016 to 2020
$780k
The Lung as an Originating Site of Autoimmunity in Rheumatoid ArthritisK23AR066712 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI DEMORUELLE, M. KRISTEN · 2014 to 2018
$776k
NHLBI NIH HHS K01 HL122394NIAID NIH HHS U19 AI050864NIAMS NIH HHS K23 AR066712NIAMS NIH HHS R01 AR051394NIAMS NIH HHS T32 AR007534NIDDK NIH HHS K24 DK110427
6 · The paper itself

Abstract

backgroundHypertension is more common in patients with rheumatoid arthritis (RA) than in the general population. It is unknown whether hypertension is due to RA-related medications or the disease itself. Therefore, we sought to investigate associations between RA-related autoantibodies, specifically antibodies to citrullinated protein antigens (ACPA) and systolic blood pressure (SBP) and diastolic blood pressure (DBP) in first-degree relatives of RA patients, who were free of RA and RA-related medications. We hypothesized that a greater number of detectable ACPA would be associated with high SBP and DBP, independent of other risk factors in these first-degree relatives.

methodsWe evaluated associations between ACPA and SBP and DBP in a cross-sectional study of 72 first-degree relatives (defined as parent, child, or sibling) of RA patients. Fifteen ACPA were measured using a Bio-Plex bead-based assay; each was dichotomized as positive/negative based on pre-specified cut-points. Analysis of covariance was used to evaluate associations between ACPA positivity and SBP and DBP, adjusting for age, sex, race, body mass index (BMI), pack-years of smoking, high sensitivity C-reactive protein (hsCRP), and current use of anti-hypertensive medications.

resultsAverage age was 51 and 69% were women. Mean SBP was 119 ± 18 and DBP was 74 ± 9 mm Hg. Thirty-three (46%) first-degree relatives were positive for ≥1 ACPA; and were younger, had lower BMI, more pack-years of smoking, and higher hsCRP concentrations compared to ACPA negative first-degree relatives. For each additional positive ACPA, SBP was 0.98 ± 0.5 mm Hg (p = 0.05) higher, and DBP was 0.66 ± 0.3 mm Hg (p = 0.04) higher. Anti-cit-fibrinogen A (211-230) positive and anti-cit-filaggrin positive first-degree relatives had 11.5 and 13.9 mm Hg higher SBP (p = 0.02) respectively. Anti-cit-clusterin, cit-filaggrin, and cit-vimentin positive first-degree relatives had 7-8 mm Hg higher DBP (p = 0.03, 0.05, 0.05 respectively), compared to being negative for these individual ACPA. Consistent with associations between ACPA, SBP, and DBP, anti-cyclic citrullinated peptides (anti-CCP2) positive first-degree relatives had 16.4± (p = 0.03) higher SBP and 12.1± mm Hg (p = 0.01) higher DBP than anti-CCP2 negative first-degree relatives.

conclusionIn first-degree relatives without RA, ACPA positivity is associated with higher SBP and DBP. Subclinical autoimmune processes and ACPA may play a role in the vascular changes potentially leading to hypertension prior to RA onset.

Indexed as

Anti-Citrullinated Protein AntibodiesBlood PressureAdultAgedArthritis, RheumatoidCross-Sectional StudiesFamilyFemaleFilaggrin ProteinsHumansMaleMiddle AgedAnti-Citrullinated Protein AntibodiesFilaggrin ProteinsFLG protein, humanAutoimmunityBlood pressureEpidemiology

Identifiers

PMID29237149
PMCPMC5788181
OpenAlexW2773797546

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.