Evidence map›Paper›PMID 29236772›Full record

ArticlePloS one2017

Age-related reduction of adaptive brain response during semantic integration is associated with gray matter reduction.

Zude Zhu, Fengjun Yang, Dongning Li, Lianjun Zhou, Ying Liu, Ying Zhang, Xuezhi Chen

Abstract read
In one paragraph

Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zude ZhuSchool of Linguistics Sciences and Arts, and Collaborative Innovation Center for Language Competence, Jiangsu Normal University, Xuzhou, China.ORCID http://orcid.org/0000-0001-9137-2560
Fengjun YangNingcheng Central Hospital, Chifeng, China.
Dongning LiNingcheng Central Hospital, Chifeng, China.
Lianjun ZhouNingcheng Central Hospital, Chifeng, China.
Ying LiuNingcheng Central Hospital, Chifeng, China.
Ying ZhangSucheng People's Hospital, Suqian, China.
Xuezhi ChenNingcheng Central Hospital, Chifeng, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While aging is associated with increased knowledge, it is also associated with decreased semantic integration. To investigate brain activation changes during semantic integration, a sample of forty-eight 25-75 year-old adults read sentences with high cloze (HC) and low cloze (LC) probability while functional magnetic resonance imaging was conducted. Significant age-related reduction of cloze effect (LC vs. HC) was found in several regions, especially the left middle frontal gyrus (MFG) and right inferior frontal gyrus (IFG), which play an important role in semantic integration. Moreover, when accounting for global gray matter volume reduction, the age-cloze correlation in the left MFG and right IFG was absent. The results suggest that brain structural atrophy may disrupt brain response in aging brains, which then show less brain engagement in semantic integration.

Indexed as

SemanticsAdultAgedAgingFemaleGray MatterHumansMagnetic Resonance ImagingMaleMiddle AgedProbability

Identifiers

PMID29236772
PMCPMC5728512

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.