Evidence map›Paper›PMID 29236660›Full record

ArticleThe Permanente journal2018

Migraine Headache Treated with Famciclovir and Celecoxib: A Case Report.

Bradford Lee Napier, Maki Morimoto, Erin Napier

Abstract readCase Reports
In one paragraph

Article in The Permanente journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 79% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Bradford Lee NapierRetired Otolaryngologist for the Hawaii Permanente Medical Group in Honolulu. bradnapiermd@mac.com.
Maki MorimotoAssistant Clinical Professor of Anesthesiology at the John A Burns School of Medicine at the University of Hawaii in Honolulu. mmorimoto@hotmail.com.
Erin NapierResearch Data Specialist at the Perelman School of Medicine at the University of Pennsylvania in Philadelphia. napierin@gmail.com.
Hawaii Permanente Medical Group · USUniversity of Hawaiʻi at Mānoa · USUniversity of Pennsylvania · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHerpes simplex virus (HSV) has been speculated to play a role in migraine headache pathophysiology. We present the first successful migraine headache treatment with therapy specifically targeting HSV infection. CASE PRESENTATION: A previously healthy 21-year-old white woman presented with a severe headache and was diagnosed with severe migraine headache disorder. She initially was treated with standard migraine headache medications without symptomatic improvement. She was then given famciclovir and celecoxib. The patient fully recovered within days and continues to enjoy significant reduction in severity and frequency of symptoms. DISCUSSION: Famciclovir and celecoxib may work synergistically against HSV. The virus may play a role in the pathophysiology of migraine headaches, and this is the first case report of successful migraine headache treatment with these medications. Further studies are needed to elucidate the efficacy of these medications in treating migraine disorder.

Indexed as

2-AminopurineAntiviral AgentsCelecoxibCyclooxygenase 2 InhibitorsFamciclovirFemaleHerpes SimplexHumansMigraine DisordersTreatment OutcomeYoung Adult2-AminopurineAntiviral AgentsCelecoxibCyclooxygenase 2 InhibitorsFamciclovir

Identifiers

PMID29236660
PMCPMC5737915
OpenAlexW2769374970

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.