ArticleEnvironmental science & technology2018
A Case Study Application of the Aggregate Exposure Pathway (AEP) and Adverse Outcome Pathway (AOP) Frameworks to Facilitate the Integration of Human Health and Ecological End Points for Cumulative Risk Assessment (CRA).
Article in Environmental science & technology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Adverse outcome pathways of titanium dioxide nanoparticles and marine heatwaves on byssal performance in mussels.Eco-Environment & Health · 2026Article
- Impacts of Plant Protection Products on Biodiversity: Limits of Risk Assessment and Avenues to Ground Liability.Risk analysis : an official publication of the Society for Risk Analysis · 2025Article
- From Evaluation to Practice: Bridging the Gap Between Air Pollution Health Risk Assessment and Policy-Making in China.China CDC weekly · 2025Article
- Transforming environmental health datasets from the comparative toxicogenomics database into chord diagrams to visualize molecular mechanisms.Frontiers in toxicology · 2024Article
- A geospatial modeling approach to quantifying the risk of exposure to environmental chemical mixtures via a common molecular target.The Science of the total environment · 2023Article
- A Framework that Considers the Impacts of Time, Cost, and Uncertainty in the Determination of the Cost Effectiveness of Toxicity-Testing Methodologies.Risk analysis : an official publication of the Society for Risk Analysis · 2022Article
- The Exposome and Toxicology: A Win-Win Collaboration.Toxicological sciences : an official journal of the Society of Toxicology · 2022Review
- The Eco-Exposome Concept: Supporting an Integrated Assessment of Mixtures of Environmental Chemicals.Environmental toxicology and chemistry · 2022Article
- Article
- Evolving Science and Practice of Risk Assessment.Risk analysis : an official publication of the Society for Risk Analysis · 2021Article
- Quantification of an Adverse Outcome Pathway Network by Bayesian Regression and Bayesian Network Modeling.Integrated environmental assessment and management · 2021Article
- Application of a combined aggregate exposure pathway and adverse outcome pathway (AEP-AOP) approach to inform a cumulative risk assessment: A case study with phthalates.Toxicology in vitro : an international journal published in association with BIBRA · 2020Article
- A Quantitative Source-to-Outcome Case Study To Demonstrate the Integration of Human Health and Ecological End Points Using the Aggregate Exposure Pathway and Adverse Outcome Pathway Frameworks.Environmental science & technology · 2019Article
- The future trajectory of adverse outcome pathways: a commentary.Archives of toxicology · 2018Article
- In silico toxicology: From structure-activity relationships towards deep learning and adverse outcome pathways.Wiley interdisciplinary reviews. Computational molecular scienceReview
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Cumulative risk assessment (CRA) methods promote the use of a conceptual site model (CSM) to apportion exposures and integrate risk from multiple stressors. While CSMs may encompass multiple species, evaluating end points across taxa can be challenging due to data availability and physiological differences among organisms. Adverse outcome pathways (AOPs) describe biological mechanisms leading to adverse outcomes (AOs) by assembling causal pathways with measurable intermediate steps termed key events (KEs), thereby providing a framework for integrating data across species. In this work, we used a case study focused on the perchlorate anion (ClO
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.