Evidence map›Paper›PMID 29236047›Full record

ArticleInternational journal of molecular sciences2017

hASC and DFAT, Multipotent Stem Cells for Regenerative Medicine: A Comparison of Their Potential Differentiation In Vitro.

Marco Saler, Laura Caliogna, Laura Botta, Francesco Benazzo, Federica Riva, Giulia Gastaldi

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 39 citations in OpenAlex.

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  20. Adipose-Derived Mesenchymal Stem Cell Treatments and Available Formulations.Current reviews in musculoskeletal medicine · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Marco SalerDepartment Clinical Surgical, Diagnostic and Pediatric Sciences, Plastic and Reconstructive Surgery Unit, University of Pavia, 27100 Pavia, Italy. marco.saler@unipv.it.ORCID 0000-0003-1512-288X
Laura CaliognaOrthopedics and Traumatology Clinic, IRCCS Policlinico San Matteo Foundation, 27100 Pavia, Italy. l.caliogna@smatteo.pv.it.
Laura BottaDepartment of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, 27100 Pavia, Italy. laura.botta@unipv.it.
Francesco BenazzoOrthopedics and Traumatology Clinic, IRCCS Policlinico San Matteo Foundation, 27100 Pavia, Italy. f.benazzo@smatteo.pv.it.
Federica RivaCentre for Health Technologies, University of Pavia, 27100 Pavia, Italy. federica.riva01@unipv.it.ORCID 0000-0001-9000-1696
Giulia GastaldiCentre for Health Technologies, University of Pavia, 27100 Pavia, Italy. giulia.gastaldi@unipv.it.ORCID 0000-0001-7387-3062
University of Pavia · ITPoliclinico San Matteo Fondazione · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adipose tissue comprises both adipose and non-adipose cells such as mesenchymal stem cells. These cells show a surface antigenic profile similar to that of bone-marrow-derived MSC. The cells derived from the dedifferentiation of mature adipocytes (DFAT) are another cell population with characteristics of stemness. The aim of this study is to provide evidence of the stemness, proliferation, and differentiation of human adipose stem cells (hASC) and DFAT obtained from human subcutaneous AT and evaluate their potential use in regenerative medicine. Cell populations were studied by histochemical and molecular biology techniques. Both hASC and DFAT were positive for MSC markers. Their proliferative capacity was similar and both populations were able to differentiate into osteogenic, chondrogenic, and adipogenic lineages. DFAT were able to accumulate lipids and their lipoprotein lipase and

Indexed as

Regenerative MedicineAdipose TissueAgedAggrecansAlkaline PhosphataseAntigens, CDCell DedifferentiationCell DifferentiationCells, CulturedCore Binding Factor Alpha 1 SubunitFemaleHumansMaleMesenchymal Stem CellsMiddle AgedMultipotent Stem CellsACAN protein, humanAggrecansAlkaline PhosphataseAntigens, CDCore Binding Factor Alpha 1 SubunitRUNX2 protein, humanSOX9 Transcription Factoradipocytesadipose tissuecell culture in vitrodedifferentiated fat adipose tissuefibroblast-likehuman adipose stem cells

Identifiers

PMID29236047
PMCPMC5751300
OpenAlexW2774262762

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.