ArticleeLife2017
Gene-free methodology for cell fate dynamics during development.
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Dynamic Landscape Analysis of cell fate decisions provides predictive models of neural development from single-cell data.PLoS biology · 2026Article
- Cell cycle oscillations in a polarity network facilitate state switching by morphogenetic cues.Science advances · 2026Article
- Unifying theories in high-dimensional biophysics: approaches, challenges and opportunities.NPJ systems biology and applications · 2026Article
- Optimality as a framework for understanding developmental robustness.Trends in cell biology · 2026Review
- Generative epigenetic landscapes map the topology and topography of cell fates.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Reconstructing Waddington's landscape from data.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Beyond metaphor: quantitative reconstruction of Waddington landscape and exploration of cellular behavior.Briefings in bioinformatics · 2025Review
- Searching for physical principles of morphogenesis.Development (Cambridge, England) · 2025Review
- Article
- Dynamical systems of fate and form in development.Seminars in cell & developmental biology · 2025Review
- From genes to patterns: five key dynamical systems concepts to decode developmental regulatory mechanisms.Development (Cambridge, England) · 2025Review
- RAP-2 and CNH-MAP4 Kinase MIG-15 confer resistance in bystander epithelium to cell-fate transformation by excess Ras or Notch activity.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Dynamic processes of fate decision in inducible bistable systems.Biophysical journal · 2024Article
- Combinatorial interpretation of BMP and WNT controls the decision between primitive streak and extraembryonic fates.Cell systems · 2024Article
- A geometrical model of cell fate specification in the mouse blastocyst.Development (Cambridge, England) · 2024Article
- A bistable autoregulatory module in the developing embryo commits cells to binary expression fates.Current biology : CB · 2023Article
- Mechanochemical feedback loops in contact-dependent fate patterning.Current opinion in systems biology · 2023Review
- CELLoGeNe - An energy landscape framework for logical networks controlling cell decisions.iScience · 2022Article
- Dynamical landscapes of cell fate decisions.Interface focus · 2022Review
- Latent space of a small genetic network: Geometry of dynamics and information.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Models of cell function that assign a variable to each gene frequently lead to systems of equations with many parameters whose behavior is obscure. Geometric models reduce dynamics to intuitive pictorial elements that provide compact representations for sparse in vivo data and transparent descriptions of developmental transitions. To illustrate, a geometric model fit to vulval development in
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.