Evidence map›Paper›PMID 29235940›Full record

ArticleEpigenetics2018

SLC9B1 methylation predicts fetal intolerance of labor.

Anna K Knight, Karen N Conneely, Varun Kilaru, Dawayland Cobb, Jennifer L Payne, Samantha Meilman, Elizabeth J Corwin, Zachary A Kaminsky, Anne L Dunlop, Alicia K Smith

Open access · bronzeAbstract read
In one paragraph

Article in Epigenetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Epigenetics and Pregnancy: Conditional Snapshot or Rolling Event.International journal of molecular sciences · 2022
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Epigenetic biomarkers and preterm birth.Environmental epigenetics · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Anna K Knighta Genetics and Molecular Biology Program , Emory University , 1462 Clifton Road, Atlanta , GA , 30322.ORCID 0000-0002-5809-050X
Karen N Conneelya Genetics and Molecular Biology Program , Emory University , 1462 Clifton Road, Atlanta , GA , 30322.
Varun Kilaruc Department of Gynecology and Obstetrics , Emory University , 101 Woodruff Circle NE, Atlanta , GA.
Dawayland Cobbc Department of Gynecology and Obstetrics , Emory University , 101 Woodruff Circle NE, Atlanta , GA.
Jennifer L Payned Women's Mood Disorders Center , Johns Hopkins School of Medicine , 550 N. Broadway, Suite 305, Baltimore , MD 21205.
Samantha Meilmand Women's Mood Disorders Center , Johns Hopkins School of Medicine , 550 N. Broadway, Suite 305, Baltimore , MD 21205.
Elizabeth J Corwine Nell Hodgson Woodruff School of Nursing , Emory University , 1520 Clifton Road, Atlanta , GA , 30322.
Zachary A Kaminskyf Department of Psychiatry , Johns Hopkins School of Medicine , 720 Rutland Avenue, Baltimore , MD , 21205 ; Johns Hopkins Bloomberg School of Public Health , 615 N. Wolfe St, Baltimore , MD , 21205.
Anne L Dunlope Nell Hodgson Woodruff School of Nursing , Emory University , 1520 Clifton Road, Atlanta , GA , 30322.
Alicia K Smitha Genetics and Molecular Biology Program , Emory University , 1462 Clifton Road, Atlanta , GA , 30322.ORCID 0000-0002-8537-5156
Emory University · USJohns Hopkins University · US

Funding

PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM008490 · NIGMS · EMORY UNIVERSITY · PI BOSS, JEREMY M. · 1993 to 2022
$8.0M
Biobehavioral Determinants of the Microbiome and Preterm Birth in Black WomenR01NR014800 · NINR · EMORY UNIVERSITY · PI CORWIN, ELIZABETH JEANNE, DUNLOP, ANNE LANG · 2013 to 2017
$2.8M
Epigenetic and Biobehavioral Determinants of Preterm Birth in Black WomenR01MD009064 · NIMHD · EMORY UNIVERSITY · PI DUNLOP, ANNE LANG, SMITH, ALICIA K · 2014 to 2018
$1.9M
NIGMS NIH HHS T32 GM008490NIMHD NIH HHS R01 MD009064NINR NIH HHS R01 NR014800
6 · The paper itself

Abstract

Fetal intolerance of labor is a common indication for delivery by Caesarean section. Diagnosis is based on the presence of category III fetal heart rate tracing, which is an abnormal heart tracing associated with increased likelihood of fetal hypoxia and metabolic acidemia. This study analyzed data from 177 unique women who, during their prenatal visits (7-15 weeks and/or 24-32 weeks) to Atlanta area prenatal care clinics, consented to provide blood samples for DNA methylation (HumanMethylation450 BeadChip) and gene expression (Human HT-12 v4 Expression BeadChip) analyses. We focused on 57 women aged 18-36 (mean 25.4), who had DNA methylation data available from their second prenatal visit. DNA methylation patterns at CpG sites across the genome were interrogated for associations with fetal intolerance of labor. Four CpG sites (P value <8.9 × 10

Indexed as

Cesarean SectionDNA MethylationAdolescentAdultCpG IslandsFemaleFetal DistressGene Expression ProfilingGestational AgeHumansPregnancyPregnancy Trimester, ThirdPrenatal CareSodium-Hydrogen ExchangersSLC9B1 protein, humanSodium-Hydrogen ExchangersBiomarker, complicationdeliveryfetal distress; NHEDC1; pregnancy; SLC9B1; sodium hydrogen exchanger

Identifiers

PMID29235940
PMCPMC5837080
OpenAlexW2772938735

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.