Evidence map›Paper›PMID 29235923›Full record

ArticleEpigenetics2018

Oncogenic BRAF mutation induces DNA methylation changes in a murine model for human serrated colorectal neoplasia.

Catherine E Bond, Cheng Liu, Futoshi Kawamata, Diane M McKeone, Winnie Fernando, Saara Jamieson, Sally-Ann Pearson, Alexandra Kane, Susan L Woods, Tamsin R M Lannagan and 12 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. BRAFiScience · 2025
    Article
  5. BRAFiScience · 2025
    Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Gut · 2022
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. BRAFOncogene · 2020
    Article
  20. Cancers · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 6 institutions in 2 countries.

Catherine E Bonda QIMR Berghofer Medical Research Institute , Brisbane , Australia.
Cheng Liua QIMR Berghofer Medical Research Institute , Brisbane , Australia.
Futoshi Kawamataa QIMR Berghofer Medical Research Institute , Brisbane , Australia.
Diane M McKeonea QIMR Berghofer Medical Research Institute , Brisbane , Australia.
Winnie Fernandoa QIMR Berghofer Medical Research Institute , Brisbane , Australia.
Saara Jamiesona QIMR Berghofer Medical Research Institute , Brisbane , Australia.
Sally-Ann Pearsona QIMR Berghofer Medical Research Institute , Brisbane , Australia.
Alexandra Kanea QIMR Berghofer Medical Research Institute , Brisbane , Australia.
Susan L Woodse The University of Western Sydney , Australia.
Tamsin R M Lannagane The University of Western Sydney , Australia.
Roshini Somashekare The University of Western Sydney , Australia.
Young Leee The University of Western Sydney , Australia.
Troy Dumenila QIMR Berghofer Medical Research Institute , Brisbane , Australia.
Gunter Hartela QIMR Berghofer Medical Research Institute , Brisbane , Australia.
Kevin J Springe The University of Western Sydney , Australia.
Jennifer Borowskya QIMR Berghofer Medical Research Institute , Brisbane , Australia.
Lochlan Fennella QIMR Berghofer Medical Research Institute , Brisbane , Australia.
Mark Bettingtona QIMR Berghofer Medical Research Institute , Brisbane , Australia.ORCID 0000-0003-0879-934X
Jason Leea QIMR Berghofer Medical Research Institute , Brisbane , Australia.ORCID 0000-0003-0879-934X
Daniel L Worthleyf South Australia Health and Medical Research Institute , Adelaide , Australia.
Barbara A Leggetta QIMR Berghofer Medical Research Institute , Brisbane , Australia.
Vicki L J Whitehalla QIMR Berghofer Medical Research Institute , Brisbane , Australia.
QIMR Berghofer Medical Research Institute · AUWestern Sydney University · AUThe University of Queensland · AUHokkaido University · JPQueensland Health · AUSouth Australian Health and Medical Research Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer is a major cause of cancer death and approximately 20% arises within serrated polyps, which are under-recognized and poorly understood. Human serrated colorectal polyps frequently exhibit both oncogenic BRAF mutation and widespread DNA methylation changes, which are important in silencing genes restraining neoplastic progression. Here, we investigated whether in vivo induction of mutant Braf is sufficient to result in coordinated promoter methylation changes for multiple cancer-related genes. The Braf

Indexed as

DNA MethylationAnimalsColorectal NeoplasmsDNA Mismatch RepairHumansHyperplasiaIntestine, SmallMice, Inbred C57BLMicrosatellite InstabilityNeoplasms, ExperimentalProto-Oncogene Proteins B-rafBRAF protein, humanBraf protein, mouseProto-Oncogene Proteins B-rafBRAFcancer biologycolorectal cancerDNA methylationmethylationmurine modelserrated neoplasia

Identifiers

PMID29235923
PMCPMC5836984
OpenAlexW2783103366

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.