ArticleNature communications2017
Sexual recombination and increased mutation rate expedite evolution of Escherichia coli in varied fitness landscapes.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Article
- Unraveling the tempo and mode of horizontal gene transfer in bacteria.Trends in microbiology · 2025Review
- Enrichment of horizontally transferred gene clusters in bacterial extracellular vesicles via non lytic mechanisms.The ISME journal · 2025Article
- Testing for the fitness benefits of natural transformation during community-embedded evolution.Microbiology (Reading, England) · 2023Article
- Minireview: Engineering evolution to reconfigure phenotypic traits in microbes for biotechnological applications.Computational and structural biotechnology journal · 2023Review
- Evolutionary action of mutations reveals antimicrobial resistance genes in Escherichia coli.Nature communications · 2022Article
- Recombination resolves the cost of horizontal gene transfer in experimental populations ofProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Relation between two evolutionary clocks reveal new insights in bacterial evolution.Access microbiology · 2022Article
- Horizontal gene transfer potentiates adaptation by reducing selective constraints on the spread of genetic variation.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Divergent Evolution of Mutation Rates and Biases in the Long-Term Evolution Experiment with Escherichia coli.Genome biology and evolution · 2020Article
- Microbial Experimental Evolution - a proving ground for evolutionary theory and a tool for discovery.EMBO reports · 2019Review
- Mathematical modeling of movement on fitness landscapes.BMC systems biology · 2019Article
- Inactivation of a Mismatch-Repair System Diversifies Genotypic Landscape ofFrontiers in microbiology · 2019Article
- Experimental Design, Population Dynamics, and Diversity in Microbial Experimental Evolution.Microbiology and molecular biology reviews : MMBR · 2018Review
- On the networked architecture of genotype spaces and its critical effects on molecular evolution.Open biology · 2018Review
- Experimental evolution heals the scars of genome-scale recoding.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
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Authors and funding
3 authors.
Funding
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Abstract
Sexual recombination and mutation rate are theorized to play different roles in adaptive evolution depending on the fitness landscape; however, direct experimental support is limited. Here we examine how these factors affect the rate of adaptation utilizing a "genderless" strain of Escherichia coli capable of continuous in situ sexual recombination. The results show that the populations with increased mutation rate, and capable of sexual recombination, outperform all the other populations. We further characterize two sexual and two asexual populations with increased mutation rate and observe maintenance of beneficial mutations in the sexual populations through mutational sweeps. Furthermore, we experimentally identify the molecular signature of a mating event within the sexual population that combines two beneficial mutations to generate a fitter progeny; this evidence suggests that the recombination event partially alleviates clonal interference. We present additional data suggesting that stochasticity plays an important role in the combinations of mutations observed.
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