Evidence map›Paper›PMID 29235378›Full record

ArticleIntegrative cancer therapies2018

The Hexane Fraction of Bursera microphylla A. Gray Induces p21-Mediated Anti-Proliferative and Pro-Apoptotic Effects in Human Cancer-Derived Cell Lines.

Sabrina Adorisio, Alessandra Fierabracci, Giulia Gigliarelli, Isabella Muscari, Lorenza Cannarile, Anna Marina Liberati, Maria Carla Marcotullio, Carlo Riccardi, Massimo Curini, Ramon Enrique Robles Zepeda and 1 more

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In one paragraph

Article in Integrative cancer therapies, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Sabrina Adorisio1 Section of Pharmacology, Department of Medicine, University of Perugia, Perugia, Italy.
Alessandra Fierabracci2 Infettivology and Clinical Trials Area, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.
Giulia Gigliarelli3 Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy.
Isabella Muscari4 Section of Onco-hematology, S. Maria Terni Hospital, Department of Surgery and Medical Sciences, University of Perugia, Perugia, Italy.
Lorenza Cannarile1 Section of Pharmacology, Department of Medicine, University of Perugia, Perugia, Italy.
Anna Marina Liberati4 Section of Onco-hematology, S. Maria Terni Hospital, Department of Surgery and Medical Sciences, University of Perugia, Perugia, Italy.
Maria Carla Marcotullio3 Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy.
Carlo Riccardi1 Section of Pharmacology, Department of Medicine, University of Perugia, Perugia, Italy.
Massimo Curini3 Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy.
Ramon Enrique Robles Zepeda5 Department of Chemical and Biological Science, University of Sonora, Hermosillo, Sonora, Mexico.
Domenico V Delfino1 Section of Pharmacology, Department of Medicine, University of Perugia, Perugia, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bursera microphylla (BM), one of the common elephant trees, is widely distributed in the Sonoran Desert in Mexico. The Seri ethnic group in the Sonoran Desert uses BM as an anti-inflammatory and painkiller drug for the treatment of sore throat, herpes labialis, abscessed tooth, and wound healing. Dried stems and leaves of BM are used in a tea to relieve painful urination and to stimulate bronchial secretion. Furthermore, BM is used for fighting venereal diseases. To investigate the effects of the hexane fraction of resin methanol extract (BM-H) on cell growth, the acute myeloid cell line (OCI-AML3) was treated with 250, 25, or 2.5 µg/mL of BM-H. The first 2 concentrations were able to significantly decrease OCI-AML3 cell number. This reduced cell number was associated with decreased S-phase, blockade of the G

Indexed as

ApoptosisBurseraCaspase 3Cell CycleCell Line, TumorCell ProliferationCyclin-Dependent Kinase Inhibitor p21HCT116 CellsHexanesHL-60 CellsHumansJurkat CellsK562 CellsMCF-7 CellsPlant ExtractsTumor Suppressor Protein p53Caspase 3Cyclin-Dependent Kinase Inhibitor p21HexanesPlant ExtractsTumor Suppressor Protein p53anti-proliferative effectBursera microphylla A. Grayhuman cancer cell linesMexican traditional medicinep21pro-apoptotic effect

Identifiers

PMID29235378
PMCPMC5950952

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.