ReviewMolecular microbiology2018
Roles of elusive translational GTPases come to light and inform on the process of ribosome biogenesis in bacteria.
Review in Molecular microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- Role of the anti-Shine-Dalgarno sequence of 16S rRNA in Flavobacterium johnsoniae.Nucleic acids research · 2026Article
- Role of the sarcin-ricin loop of 23S rRNA in biogenesis of the 50S ribosomal subunit.RNA (New York, N.Y.) · 2025Article
- Identification of leader-trailer helices of precursor ribosomal RNA in all phyla of bacteria and archaea.RNA (New York, N.Y.) · 2024Article
- The Structural and Molecular Mechanisms ofMolecules (Basel, Switzerland) · 2024Review
- Ribosome biogenesis factors-from names to functions.The EMBO journal · 2023Review
- Novel rRNA transcriptional activity of NhaR revealed by its growth recovery for theFrontiers in molecular biosciences · 2023Article
- Genomic and Phenotypic Comparisons Reveal Distinct Variants ofApplied and environmental microbiology · 2022Article
- Diverse Aquatic Animal Matrices Play a Key Role in Survival and Potential Virulence of Non-O1/O139Frontiers in microbiology · 2022Article
- BipA exerts temperature-dependent translational control of biofilm-associated colony morphology ineLife · 2021Article
- The Yersinia pestis GTPase BipA Promotes Pathogenesis of Primary Pneumonic Plague.Infection and immunity · 2021Article
- Functions and Regulation of Translation Elongation Factors.Frontiers in molecular biosciences · 2021Review
- Translational GTPase BipA Is Involved in the Maturation of a Large Subunit of Bacterial Ribosome at Suboptimal Temperature.Frontiers in microbiology · 2021Article
- A comprehensive spectral assay library to quantify the Escherichia coli proteome by DIA/SWATH-MS.Scientific data · 2020Article
- Functional Analysis of BipA in E. coli Reveals the Natural Plasticity of 50S Subunit Assembly.Journal of molecular biology · 2020Article
- Multicopy Suppressor Analysis of Strains Lacking Cytoplasmic Peptidyl-ProlylInternational journal of molecular sciences · 2020Article
- Alterations in the ribosomal protein bL12 of E. coli affecting the initiation, elongation and termination of protein synthesis.Biochimie · 2020Article
- Translational regulation of environmental adaptation in bacteria.The Journal of biological chemistry · 2020Review
- The Impact of the Stringent Response on TRAFAC GTPases and Prokaryotic Ribosome Assembly.Cells · 2019Review
- ABCF ATPases Involved in Protein Synthesis, Ribosome Assembly and Antibiotic Resistance: Structural and Functional Diversification across the Tree of Life.Journal of molecular biology · 2019Article
- Translation initiation factor IF2 contributes to ribosome assembly and maturation during cold adaptation.Nucleic acids research · 2019Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Protein synthesis relies on several translational GTPases (trGTPases), related proteins that couple the hydrolysis of GTP to specific molecular events on the ribosome. Most bacterial trGTPases, including IF2, EF-Tu, EF-G and RF3, play well-known roles in translation. The cellular functions of LepA (also termed EF4) and BipA (also termed TypA), conversely, have remained enigmatic. Recent studies provide compelling in vivo evidence that LepA and BipA function in biogenesis of the 30S and 50S subunit respectively. These findings have important implications for ribosome biogenesis in bacteria. Because the GTPase activity of each of these proteins depends on interactions with both ribosomal subunits, some portion of 30S and 50S assembly must occur in the context of the 70S ribosome. In this review, we introduce the trGTPases of bacteria, describe the new functional data on LepA and BipA, and discuss the how these findings shape our current view of ribosome biogenesis in bacteria.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.