ArticleInternational journal of cancer2018
Heat shock protein 70 and tumor-infiltrating NK cells as prognostic indicators for patients with squamous cell carcinoma of the head and neck after radiochemotherapy: A multicentre retrospective study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG).
Open access · hybridAbstract readMulticenter Study
In one paragraph
Article in International journal of cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 3 pooled it
2.9field-weighted citation impact, top 8% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Prognostic Significance of Tumor-Infiltrating Natural Killer Cells in Solid Tumors: A Systematic Review and Meta-Analysis.Frontiers in immunology · 2020Pooled it
- The prognostic role of NK cells and their ligands in squamous cell carcinoma of the head and neck: a systematic review and meta-analysis.Oncoimmunology · 2020Pooled it
- Pooled it
- Neoadjuvant sintilimab in combination with concurrent chemoradiotherapy for locally advanced gastric or gastroesophageal junction adenocarcinoma: a single-arm phase 2 trial.Nature communications · 2023Trial
- Tumor microenvironment-driven natural killer cell diversity: mechanisms and therapeutic opportunities.Cancer biology & medicine · 2026Review
- The immune microenvironment of HPV-associated cancers: from viral oncogenesis to immunotherapy response.Frontiers in immunology · 2026Review
- Does immunotherapy hold great promise in endometrial cancer care?Frontiers in immunology · 2026Review
- Article
- Article
- RAS70 peptide targets multiforme glioblastoma by binding to the plasma membrane heat shock protein HSP70.Frontiers in oncology · 2025Article
- Article
- A comprehensive and longitudinal evaluation of the different populations of lymphoid and myeloid cells in the peripheral blood of patients treated with chemoradiotherapy for head and neck cancer.Cancer immunology, immunotherapy : CII · 2024Article
- Transcription Factor E2F7 Hampers the Killing Effect of NK Cells against Colorectal Cancer Cells via Activating RAD18 Transcription.Journal of microbiology and biotechnology · 2024Article
- Natural killer cells: a future star for immunotherapy of head and neck squamous cell carcinoma.Frontiers in immunology · 2024Review
- X-ray reflectivity study of the heat shock protein Hsp70 interaction with an artificial cell membrane model.Scientific reports · 2023Article
- Article
- Comparing TIMP-1 and Hsp70 in Blood and Saliva as Potential Prognostic Markers in HNSCC.Biomedicines · 2022Article
- Targeting Heat Shock Proteins in Malignant Brain Tumors: From Basic Research to Clinical Trials.Cancers · 2022Review
- Successful secondary radical operation on unretractable metastatic platinum-sensitive recurrent ovarian cancer by immunotherapy: a case report.Annals of translational medicine · 2022Article
- Targeted Hsp70 fluorescence molecular endoscopy detects dysplasia in Barrett's esophagus.European journal of nuclear medicine and molecular imaging · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors at 5 institutions in 1 country.
Stefan StanglDepartment of Radiation Oncology, Klinikum rechts der Isar, Technische Universität München (TUM), Munich, Germany.
Nikoletta TontchevaMVZ Radiologie und Strahlentherapie Nürnberg, Nürnberg, Germany.
Wolfgang SievertDepartment of Radiation Oncology, Klinikum rechts der Isar, Technische Universität München (TUM), Munich, Germany.
Maxim ShevtsovDepartment of Radiation Oncology, Klinikum rechts der Isar, Technische Universität München (TUM), Munich, Germany.
Minli NiuDepartment of Radiation Oncology, Klinikum rechts der Isar, Technische Universität München (TUM), Munich, Germany.
Thomas E SchmidDepartment of Radiation Oncology, Klinikum rechts der Isar, Technische Universität München (TUM), Munich, Germany.
Steffi PigorschDepartment of Radiation Oncology, Klinikum rechts der Isar, Technische Universität München (TUM), Munich, Germany.
Stephanie E CombsDepartment of Radiation Oncology, Klinikum rechts der Isar, Technische Universität München (TUM), Munich, Germany.
Bernhard HallerInstitute of Medical Informatics, Statistics and Epidemiology, Technische Universität München (TUM), Munich, Germany.
Panagiotis BalermpasDepartment of Radiotherapy and Oncology, Goethe University Frankfurt, Germany.
Franz RödelDepartment of Radiotherapy and Oncology, Goethe University Frankfurt, Germany.
Claus RödelDepartment of Radiotherapy and Oncology, Goethe University Frankfurt, Germany.
Emmanouil FokasDepartment of Radiotherapy and Oncology, Goethe University Frankfurt, Germany.ORCID 0000-0003-1601-6165
Mechthild KrauseOncoRay - National Centre for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Annett LingeOncoRay - National Centre for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Fabian LohausOncoRay - National Centre for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Michael BaumannOncoRay - National Centre for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Inge TinhoferDepartment of Radiooncology and Radiotherapy, Charite University Hospital Berlin, Berlin, Germany.
Volker BudachDepartment of Radiooncology and Radiotherapy, Charite University Hospital Berlin, Berlin, Germany.
Martin StuschkeDepartment of Radiotherapy, Medical Faculty, University of Duisburg-Essen, Essen, Germany.
Anca-Ligia GrosuDepartment of Radiation Oncology, Medical Faculty, Medical Centre, University of Freiburg, Germany.
Amir AbdollahiGerman Cancer Research Centre (DKFZ), Heidelberg and German Research Consortium (DKTK), Heidelberg, Germany.
Jürgen DebusGerman Cancer Research Centre (DKFZ), Heidelberg and German Research Consortium (DKTK), Heidelberg, Germany.
Claus BelkaGerman Cancer Research Centre (DKFZ), Heidelberg and German Research Consortium (DKTK), Munich, Germany.
Cornelius MaihöferGerman Cancer Research Centre (DKFZ), Heidelberg and German Research Consortium (DKTK), Munich, Germany.
David MönnichDepartment of Radiation Oncology, Faculty of Medicine and University Hospital Tübingen, Eberhard Karls University Tübingen, Tübingen, Germany.
Daniel ZipsDepartment of Radiation Oncology, Faculty of Medicine and University Hospital Tübingen, Eberhard Karls University Tübingen, Tübingen, Germany.
Gabriele MulthoffDepartment of Radiation Oncology, Klinikum rechts der Isar, Technische Universität München (TUM), Munich, Germany.ORCID 0000-0002-2616-3137
German Cancer Research Center · DEGoethe University Frankfurt · DETechnical University of Munich · DETUM Klinikum · DEUniversity of Freiburg · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tumor cells frequently overexpress heat shock protein 70 (Hsp70) and present it on their cell surface, where it can be recognized by pre-activated NK cells. In our retrospective study the expression of Hsp70 was determined in relation to tumor-infiltrating CD56
Indexed as
Cyclin-Dependent Kinase Inhibitor p16DNA, ViralFemaleHead and Neck NeoplasmsHSP70 Heat-Shock ProteinsHuman papillomavirus 16HumansImmunohistochemistryKiller Cells, NaturalLymphocytes, Tumor-InfiltratingMaleMiddle AgedNeoplasm StagingPrognosisRetrospective StudiesSquamous Cell Carcinoma of Head and NeckCDKN2A protein, humanCyclin-Dependent Kinase Inhibitor p16DNA, ViralHSP70 Heat-Shock ProteinsTP53 protein, humanTumor Suppressor Protein p53Hsp70IHCNK cellsprognostic biomarkerretrospective trialSCCHN
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.