Evidence map›Paper›PMID 29235074›Full record

ReviewDrug delivery and translational research2018

Twin-screw extrusion of sustained-release oral dosage forms and medical implants.

Xin Feng, Feng Zhang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Drug delivery and translational research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Xin FengDepartment of Pharmaceutics and Drug Delivery, The University of Mississippi, University, MS, USA.
Feng ZhangCollege of Pharmacy, University of Texas at Austin, Austin, TX, USA. feng.zhang@austin.utexas.edu.ORCID http://orcid.org/0000-0002-5377-5841

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Most of published reviews of twin-screw extrusion focused on its application for enhancing the bioavailability of amorphous solid dispersions while few of them focused on its use for manufacturing sustained-release oral dosage forms and medical implants, despite the considerable interest and success this process has garnered both in academia and in the pharmaceutical industry. Compared to conventional batch processing, twin-screw extrusion offers the advantages of continuous processing and the ability to prepare oral dosage forms and medical implants that have unique physicochemical and drug release attributes. This review provides an in-depth analysis of the formulation composition and processing conditions of twin-screw extrusion and how these factors affect the drug release properties of sustained-release dosage forms. This review also illustrates the unique advantages of this process by presenting case studies of a wide variety of commercial sustained-release products manufactured using twin-screw extrusion.

Indexed as

Administration, OralBiological AvailabilityDelayed-Action PreparationsDrug CompoundingDrug ImplantsDrug LiberationExcipientsSolubilityDelayed-Action PreparationsDrug ImplantsExcipients3-D printingContinuous processingImplantsMatrix tabletsMelt extrusionSustained release

Identifiers

PMID29235074

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.