ArticleJournal of the American Society for Mass Spectrometry2018
Simple Approach for De Novo Structural Identification of Mannose Trisaccharides.
Article in Journal of the American Society for Mass Spectrometry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Unraveling Cross-Ring Dissociation Mechanisms of Hexoses in Collision-Induced Dissociation.The journal of physical chemistry. A · 2026Article
- Isomeric diversity of GlcNAc(ManScientific reports · 2026Article
- Unusual free trisaccharides in caprine colostrum discovered by logically derived sequence tandem mass spectrometry.Scientific reports · 2025Article
- Collision-Induced Dissociations of Linear Hexose and Disaccharides with Linear Hexose at the Reducing End.The journal of physical chemistry. A · 2024Article
- High Abundance of Unusual High MannoseACS omega · 2024Article
- Chromatograms and Mass Spectra of High-Mannose and PaucimannoseJournal of proteome research · 2024Article
- Gas Phase Conformation of Trisaccharides and Core Pentasaccharide: A Three-Step Tree-Based Sampling and Quantum Mechanical Computational Approach.Molecules (Basel, Switzerland) · 2023Article
- Identification of the High MannoseAnalytical chemistry · 2023Article
- Unusual free oligosaccharides in human bovine and caprine milk.Scientific reports · 2022Article
- A Multidimensional Mass Spectrometry-Based Workflow forJournal of the American Society for Mass Spectrometry · 2021Article
- Structural identification of N-glycan isomers using logically derived sequence tandem mass spectrometry.Communications chemistry · 2021Article
- Logically derived sequence tandem mass spectrometry for structural determination of Galactose oligosaccharides.Glycoconjugate journal · 2021Article
- Toward Automatic and Comprehensive Glycan Characterization by Online PGC-LC-EED MS/MS.Analytical chemistry · 2020Article
- Simple Method for De Novo Structural Determination of Underivatised Glucose Oligosaccharides.Scientific reports · 2018Article
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Authors and funding
5 authors.
Funding
Abstract
Oligosaccharides have diverse functions in biological systems. However, the structural determination of oligosaccharides remains difficult and has created a bottleneck in carbohydrate research. In this study, a new approach for the de novo structural determination of underivatized oligosaccharides is demonstrated. A low-energy collision-induced dissociation (CID) of sodium ion adducts was used to facilitate the cleavage of desired chemical bonds during the dissociation. The selection of fragments for the subsequent CID was guided using a procedure that we built from the understanding of the saccharide dissociation mechanism. The linkages, anomeric configurations, and branch locations of oligosaccharides were determined by comparing the CID spectra of oligosaccharide with the fragmentation patterns based on the dissociation mechanism and our specially prepared disaccharide CID spectrum database. The usefulness of this method was demonstrated to determine the structures of several mannose trisaccharides. This method can also be applied in the structural determination of oligosaccharides larger than trisaccharides and containing hexose other than mannose if authentic standards are available. Graphical Abstract.
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