Trial reportJournal of assisted reproduction and genetics2018
Low versus high volume of culture medium during embryo transfer: a randomized clinical trial.
Trial report in Journal of assisted reproduction and genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03350646 (Low Versus High Volume of Culture Medium During Embryo Transfer), which is not on this map. Cited by 9 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Low Versus High Volume of Culture Medium During Embryo Transfer: a Randomized Clinical Trial.
Who cites it
9 citing papers in PubMed, 4 syntheses or guidelines pooled it, 12 citations in OpenAlex.
- ESHRE recommendations on Good Practice in the IVF laboratory†.Human reproduction (Oxford, England) · 2026Guideline
- How embryo retention affects assisted reproductive technology outcomes: a systematic review and meta-analysis.Archives of gynecology and obstetrics · 2025Pooled it
- Interventions to optimize embryo transfer in women undergoing assisted conception: a comprehensive systematic review and meta-analyses.Human reproduction update · 2022Pooled it
- Endometrial injection of embryo culture supernatant for subfertile women in assisted reproduction.The Cochrane database of systematic reviews · 2020Pooled it
- Effects of Fibroid Size and Hyaluronan-Enriched Transfer Medium on Clinical Pregnancy and Live Birth: A Retrospective Study.Journal of clinical medicine · 2026Article
- A temporal extracellular transcriptome atlas of human pre-implantation development.Cell genomics · 2024Article
- The effect of embryo catheter loading technique on pregnancy rate.Reproduction & fertility · 2022Article
- Expression of pro-apoptotic and anti-apoptotic proteins in granulosa cells of women with diminished ovarian reserve.Journal of assisted reproduction and genetics · 2022Article
- Evidence and consensus on technical aspects of embryo transfer.Human reproduction open · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this prospective randomized control trial was to evaluate if the use of two different volumes (20-25 vs 40-45 μl) of media used for embryo transfer affects the clinical outcomes in fresh in vitro fertilization (IVF) cycles.
methodsIn total, 236 patients were randomized in two groups, i.e., "low volume" group (n = 118) transferring the embryos with 20-25 μl of medium and "high volume" group (n = 118) transferring the embryos with 40-45 μl of medium. The clinical pregnancy, implantation, and ongoing pregnancy rates were compared between the two groups.
resultsNo statistically significant differences were observed in clinical pregnancy (46.8 vs 54.3%, p = 0.27), implantation (23.7 vs 27.8%, p = 0.30), and ongoing pregnancy (33.3 vs 40.0%, p = 0.31) rates between low and high volume group, respectively.
conclusionHigher volume of culture medium to load the embryo into the catheter during embryo transfer does not influence the clinical outcome in fresh IVF cycles. TRIAL REGISTRATION NUMBER: NCT03350646.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.