Evidence map›Paper›PMID 29234866›Full record

ReviewHerzschrittmachertherapie & Elektrophysiologie2018

Atrial thrombogenesis in atrial fibrillation : Results from atrial fibrillation models and AF-patients.

Alicja Bukowska, Matthias Hammwöhner, Domenico Corradi, Wisno Mahardhika, Andreas Goette

Erratum issuedOpen access · bronzeAbstract readReview
PubMed Publisher
In one paragraph

Review in Herzschrittmachertherapie & Elektrophysiologie, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 27 citations in OpenAlex.

  1. Determinants of left atrium thrombi in scheduled cardioversion: an ENSURE-AF study analysis.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2019
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  5. Atrial cardiomyopathy revisited-evolution of a concept: a clinical consensus statement of the European Heart Rhythm Association (EHRA) of the ESC, the Heart Rhythm Society (HRS), the Asian Pacific Heart Rhythm Society (APHRS), and the Latin American Heart Rhythm Society (LAHRS).Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
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  11. Cytotoxic CD8Cells · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Alicja BukowskaWorking Group of Molecular Electrophysiology, Institute of Clinical Chemistry and Pathobiochemistry, Medical Faculty, Otto von Guericke University Magdeburg, Magdeburg, Germany.
Matthias HammwöhnerDepartment of Cardiology and Intensive Care Medicine, St. Vincenz Hospital, Am Busdorf 2, 33098, Paderborn, Germany.
Domenico CorradiDepartment of Biomedical, Biotechnological, and Translational Sciences (S.Bi.Bi.T.), Unit of Pathology, University of Parma, Parma, Italy.
Wisno MahardhikaDepartment of Cardiology and Intensive Care Medicine, St. Vincenz Hospital, Am Busdorf 2, 33098, Paderborn, Germany.
Andreas GoetteWorking Group of Molecular Electrophysiology, Institute of Clinical Chemistry and Pathobiochemistry, Medical Faculty, Otto von Guericke University Magdeburg, Magdeburg, Germany. andreas.goette@vincenz.de.
St. Vincenz-Krankenhaus Limburg · DEOtto-von-Guericke University Magdeburg · DEUniversity of Parma · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atrial fibrillation (AF) is the most common cause of thromboembolic complications. The risk of suffering a thromboembolic complication depends on the accompanying cardiac risk factors and the patient's age. For patients who have an increased risk, which is now classified using the CHA2DS2-VASc score, initiation of long-term oral anticoagulation is the first-line treatment. In AF, thrombi arise in the left atrial appendage. The present review will summarize the basic pathophysiology of thrombogenesis in AF and will provide the molecular basis of a process called prothrombotic endocardial remodeling. Despite oral anticoagulation being a central component of therapy, the present results can be used to support concomitant therapy with statins, angiotensin II blockers, etc. to inhibit atrial thromogenesis.

Indexed as

Age FactorsAngiotensin-Converting Enzyme InhibitorsAngiotensin IIAnimalsAnticoagulantsAtrial AppendageAtrial FibrillationAtrial RemodelingDisease Models, AnimalEndocardiumHeart AtriaHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMice, TransgenicPlatelet ActivationRisk AssessmentAngiotensin-Converting Enzyme InhibitorsAngiotensin IIAnticoagulantsHydroxymethylglutaryl-CoA Reductase InhibitorsAngiotensin IIAnticoagulationEndocardiumStrokeTherapy

Identifiers

PMID29234866
OpenAlexW2774481559

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.