ReviewWorld journal of surgery2018
Urbanization in Sub-Saharan Africa: Declining Rates of Chronic and Recurrent Infection and Their Possible Role in the Origins of Non-communicable Diseases.
Review in World journal of surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Global prevalence and trends in hypertension and type 2 diabetes mellitus among slum residents: a systematic review and meta-analysis.BMJ open · 2022Pooled it
- Disparities in the Prevalence of Childhood Obesity-Related Comorbidities: A Systematic Review.Frontiers in public health · 2022Pooled it
- Prevalence and risk factors of type-2 diabetes mellitus in Ethiopia: systematic review and meta-analysis.Scientific reports · 2021Pooled it
- The global burden of non-communicable diseases attributable to behavioral risk factors and its trends from 1990 to 2021.Journal of advanced research · 2026Article
- Review
- A comparative study of cardiovascular diseases risk profile among HIV-positive individuals on antiretroviral therapy and HIV-negative controls in a secondary healthcare setting in southwest Nigeria.BMC infectious diseases · 2026Article
- Prevalence and Determinants of Intestinal Parasitic Infections Among Diabetes Mellitus Patients at Debre Tabor Comprehensive Specialized Hospital, North-Central Ethiopia: A Cross-Sectional Study.Health science reports · 2025Article
- Aspartate Is A Determinant of TNF-α Biogenesis in Sub-Saharan Africa: Insight Into the Pathogenesis of Noncommunicable Diseases.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Application of decision analytic modelling to cardiovascular disease prevention in Sub-Saharan Africa: a systematic review.Communications medicine · 2025Article
- Article
- Article
- Impact of urban greening on population health in sub-Saharan Africa: a scoping review protocol.BMJ open · 2024Article
- Article
- Article
- Population health and sociodemographic variables as predictors of access to cardiac medicine and surgery in Haiti.Global health research and policy · 2023Article
- Article
- Changing Dietary Habits: The Impact of Urbanization and Rising Socio-Economic Status in Families from Burkina Faso in Sub-Saharan Africa.Nutrients · 2022Article
- Development and validation of the Soweto Coping Scale: A mixed-methods, population-based study of adults living in Soweto, South Africa.Journal of affective disorders · 2022Article
- Epigenetic age acceleration in the emerging burden of cardiometabolic diseases among migrant and non-migrant African populations: the population based cross-sectional RODAM study.The lancet. Healthy longevity · 2021Article
- Urban living in healthy Tanzanians is associated with an inflammatory status driven by dietary and metabolic changes.Nature immunology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundNon-communicable diseases (NCDs), such as atherosclerosis and cancers, are a leading cause of death worldwide. An important, yet poorly explained epidemiological feature of NCDs is their low incidence in under developed areas of low-income countries and rising rates in urban areas.
methodsWith the goal of better understanding how urbanization increases the incidence of NCDs, we provide an overview of the urbanization process in sub-Saharan Africa, discuss gene expression differences between rural and urban populations, and review the current NCD determinant model. We conclude by identifying research priorities.
resultsDeclining rates of chronic and recurrent infection are the hallmark of urbanization in sub-Saharan Africa. Gene profiling studies show urbanization results in complex molecular changes, with almost one-third of the peripheral blood leukocyte transcriptome altered. The current NCD determinant model could be improved by including a possible effect from declining rates of infection and expanding the spectrum of diseases that increase with urbanization.
conclusionsUrbanization in sub-Saharan Africa provides a unique opportunity to investigate the mechanism by which the environment influences disease epidemiology. Research priorities include: (1) studies to define the relationship between infection and risk factors for NCDs, (2) explaining the observed differences in the inflammatory response between rural and urban populations, and (3) identification of animal models that simulate the biological changes that occurs with urbanization. A better understanding of the biological changes that occur with urbanization could lead to new prevention and treatment strategies for some of the most common surgical diseases in high-income countries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.