Evidence map›Paper›PMID 29234676›Full record

ArticleBioMed research international2017

Healing and Antisecretory Effects of Aqueous Extract of

A P Amang, C Mezui, G T Siwe, J Emakoua, G Mbah, E Z Nkwengoua, G E Enow-Orock, P V Tan

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 14 citations in OpenAlex.

  1. Gastric Ulcer Healing Property ofFrontiers in pharmacology · 2021
    Article
  2. Rosmarinic Acid Enriched Fraction fromBioMed research international · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

A P AmangDepartment of Biological Sciences, Faculty of Science, University of Maroua, P.O. Box 814, Maroua, Cameroon.
C MezuiDepartment of Biological Sciences, Higher Teachers' Training College, University of Yaoundé I, P.O. Box 047, Yaoundé, Cameroon.
G T SiweDepartment of Animal Biology & Physiology, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon.
J EmakouaDepartment of Animal Biology & Physiology, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon.
G MbahDepartment of Animal Biology & Physiology, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon.
E Z NkwengouaDepartment of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon.
G E Enow-OrockDepartment of Biomedical Sciences, Faculty of Health Sciences, University of Buea, P.O. Box 63, Buea, Cameroon.
P V TanDepartment of Animal Biology & Physiology, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon.ORCID 0000-0001-7112-7912
Université de Yaoundé I · CMUniversity of Buea · CMUniversity of Maroua · CM

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis work investigated the healing and antisecretory effects of the aqueous extract of MATERIALS AND

methods"Unhealed gastric ulcers" were induced using indomethacin following the establishment of acetic-acid-induced chronic gastric ulcers. The extract (200 and 400 mg/kg, per os) was administered concomitantly with indomethacin (1 mg/kg, subcutaneously). The effects of the extract on both basal and histamine-stimulated gastric acid secretion were determined. Mucus secretion and oxidative stress parameters were measured, and histological assessment of ulcer healing was carried out.

resultsThe extract significantly promoted the healing process in rats subjected to "unhealed gastric ulcers" (82.4-88.5% healing rates). Treatment with the extract significantly reduced the basal (25.95-49.51% reduction rates) and histamine-stimulated (24.25-47.41%) acid secretions. The healing effect of the extract was associated with a significant (

conclusionThe abilities of the extract to increase mucus secretion, to reinforce antioxidant status, and to inhibit acid secretion would be some of the mechanisms by which this extract would accelerate the healing process in "unhealed gastric ulcers."

Indexed as

AcanthaceaeAcetic AcidAnimalsAntioxidantsDisease Models, AnimalGastric MucosaHumansIndomethacinOxidative StressPlant ExtractsRatsStomach UlcerWound HealingAcetic AcidAntioxidantsIndomethacinPlant Extracts

Identifiers

PMID29234676
PMCPMC5695077
OpenAlexW2765348481

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.