Evidence map›Paper›PMID 29234634›Full record

ArticleLiver cancer2017

Association of Serum Ferritin with Diabetes and Alcohol in Patients with Non-Viral Liver Disease-Related Hepatocellular Carcinoma.

Rohan C Siriwardana, Madunil A Niriella, Anuradha Dassanayake, Dileepa Ediriweera, Bhagya Gunetilleke, Thenuka Sivasundaram, Janaka de Silva

Open access · goldAbstract read
In one paragraph

Article in Liver cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Mechanisms of hepatocellular carcinoma progression.World journal of gastroenterology · 2019
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Rohan C SiriwardanaDepartment of Surgery, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
Madunil A NiriellaDepartment of Medicine, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
Anuradha DassanayakeDepartment of Pharmacology, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
Dileepa EdiriweeraDepartment of ICT Centre, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
Bhagya GunetillekeDepartment of Surgery, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
Thenuka SivasundaramDepartment of Surgery, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
Janaka de SilvaDepartment of Medicine, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
University of Kelaniya · LK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionNon-alcoholic fatty liver disease is a leading cause for hepatocellular carcinoma (HCC) in Sri Lanka. Diabetes mellitus, alcohol abuse, and liver inflammation are known to increase the risk of HCC. The present study evaluates serum ferritin levels in a cohort of patients with non-viral HCC (nvHCC). METHODOLOGY: Consecutive patients with nvHCC presenting to the Colombo North Liver transplant Service, Ragama, from January 2012 to July 2013 were investigated. All were negative for hepatitis B and C. At registration, 5 mL of serum was separated into plain tubes, stored at -80°C and analysed for ferritin using an enzyme-linked immunosorbent assay. Correlation between the serum ferritin and patient risk factors, liver status, and tumour characteristics were analysed.

resultsThere were 93 patients with nvHCC (median age 65 [12-82] years; 82 [88.2%] males). The median ferritin level was 246.2 μg/L, and 38 (40.86%) patients had elevated ferritin. Non-diabetics (median 363.5 mg/L,

conclusionIn patients with nvHCC, serum ferritin levels are higher in non-diabetics and alcoholics.

Indexed as

BloodFerritinHepatocellular carcinoma, diagnosisHepatocellular carcinoma, etiology

Identifiers

PMID29234634
PMCPMC5704680
OpenAlexW2749345191

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.