Evidence map›Paper›PMID 29234487›Full record

ReviewGenes & cancer2017

Alcohol, stem cells and cancer.

Shoujun Gu, Bao-Ngoc Nguyen, Shuyun Rao, Shulin Li, Kirti Shetty, Asif Rashid, Vivek Shukla, Chu-Xia Deng, Lopa Mishra, Bibhuti Mishra

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Genes & cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shoujun GuDepartment of Surgery, Center for Translational Medicine, George Washington University, Washington, DC, USA.
Bao-Ngoc NguyenDepartment of Surgery, Center for Translational Medicine, George Washington University, Washington, DC, USA.
Shuyun RaoDepartment of Surgery, Center for Translational Medicine, George Washington University, Washington, DC, USA.
Shulin LiDepartments of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Kirti ShettyDivision of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Asif RashidDepartments of Gastroenterology and Liver Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Vivek ShuklaThoracic and Gastrointestinal Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA.
Chu-Xia DengDepartment of Surgery, Center for Translational Medicine, George Washington University, Washington, DC, USA.
Lopa MishraDepartment of Surgery, Center for Translational Medicine, George Washington University, Washington, DC, USA.
Bibhuti MishraDepartment of Surgery, Center for Translational Medicine, George Washington University, Washington, DC, USA.

Funding

Targeting CDK4 in TGS-B Inactivated Gastrointestinal CancersP01CA130821 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI MISHRA, LOPA · 2008 to 2013
$6.9M
Gene-Product Auto-Targeting to Tumor VesselsR01CA120895 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LI, SHULIN · 2007 to 2025
$4.8M
Role of Beta Spectrin and Smad in Alcohol-Induced Liver and GI Cell ProliferationR01AA023146 · NIAAA · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Lopa Mishra · 2013 to 2026
$4.6M
Low Electric Field-Based Gene Delivery of IL-30 Gene Therapy for Liver InjuryR01DK102767 · NIDDK · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LI, SHULIN · 2015 to 2019
$1.8M
The role of Poly-ADP-Ribose Polymerase in angiogenesis of ischemic-diabetic woundsK08HL129072 · NHLBI · GEORGE WASHINGTON UNIVERSITY · PI NGUYEN, BAO-NGOC · 2018 to 2022
$747k
Molecular Mechanisms and Translational studies in Colon CancerI01BX003732 · VA · U.S. DEPT/VETS AFFAIRS MEDICAL CENTER · PI MISHRA, LOPA · 2017 to 2019
–
BLRD VA I01 BX003732NCI NIH HHS P01 CA130821NCI NIH HHS R01 CA120895NHLBI NIH HHS K08 HL129072NIAAA NIH HHS R01 AA023146NIDDK NIH HHS R01 DK102767
6 · The paper itself

Abstract

Dosage, gender, and genetic susceptibility to the effects of alcohol remained only partially elucidated. In this review, we summarize the current knowledge of the mechanisms underlying the role of alcohol in liver and gastrointestinal cancers. In addition, two recent pathways- DNA repair and TGF-β signaling which provide new insights into alcohol in the regulation of cancers and stem cells are also discussed here.

Indexed as

alcoholcancerDNA repairstem cellsTGF-β

Identifiers

PMID29234487
PMCPMC5724803

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.