Evidence map›Paper›PMID 29234470›Full record

ArticleBeilstein journal of organic chemistry2017

Asymmetric synthesis of propargylamines as amino acid surrogates in peptidomimetics.

Matthias Wünsch, David Schröder, Tanja Fröhr, Lisa Teichmann, Sebastian Hedwig, Nils Janson, Clara Belu, Jasmin Simon, Shari Heidemeyer, Philipp Holtkamp and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Beilstein journal of organic chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Synthesis and Preclinical Evaluation of Two NovelMolecules (Basel, Switzerland) · 2024
    Article
  4. Article
  5. Review
  6. 1,4-Disubstituted 1Frontiers in chemistry · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Matthias WünschOrganic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, Universitätsstraße 25, D-33615 Bielefeld, Germany.ORCID 0000-0002-3244-8374
David SchröderOrganic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, Universitätsstraße 25, D-33615 Bielefeld, Germany.ORCID 0000-0002-7249-4156
Tanja FröhrOrganic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, Universitätsstraße 25, D-33615 Bielefeld, Germany.
Lisa TeichmannOrganic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, Universitätsstraße 25, D-33615 Bielefeld, Germany.
Sebastian HedwigOrganic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, Universitätsstraße 25, D-33615 Bielefeld, Germany.
Nils JansonOrganic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, Universitätsstraße 25, D-33615 Bielefeld, Germany.ORCID 0000-0002-9681-5698
Clara BeluOrganic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, Universitätsstraße 25, D-33615 Bielefeld, Germany.
Jasmin SimonOrganic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, Universitätsstraße 25, D-33615 Bielefeld, Germany.ORCID 0000-0002-8309-2267
Shari HeidemeyerOrganic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, Universitätsstraße 25, D-33615 Bielefeld, Germany.ORCID 0000-0002-9254-7796
Philipp HoltkampOrganic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, Universitätsstraße 25, D-33615 Bielefeld, Germany.
Jens RudlofOrganic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, Universitätsstraße 25, D-33615 Bielefeld, Germany.
Lennard KlemmeOrganic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, Universitätsstraße 25, D-33615 Bielefeld, Germany.
Alessa HinzmannOrganic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, Universitätsstraße 25, D-33615 Bielefeld, Germany.ORCID 0000-0002-1893-7892
Beate NeumannOrganic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, Universitätsstraße 25, D-33615 Bielefeld, Germany.
Hans-Georg StammlerOrganic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, Universitätsstraße 25, D-33615 Bielefeld, Germany.ORCID 0000-0002-0918-7057
Norbert SewaldOrganic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, Universitätsstraße 25, D-33615 Bielefeld, Germany.ORCID 0000-0002-0309-2655

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The amide moiety of peptides can be replaced for example by a triazole moiety, which is considered to be bioisosteric. Therefore, the carbonyl moiety of an amino acid has to be replaced by an alkyne in order to provide a precursor of such peptidomimetics. As most amino acids have a chiral center at C

Indexed as

amino acid analogous side chainsdesilylationEllman’s chiral sulfinamideintramolecular Huisgen reactionpeptidomimeticspropargylaminesrearrangement to α,β-unsaturated imines

Identifiers

PMID29234470
PMCPMC5704752

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.