ArticleEvidence-based complementary and alternative medicine : eCAM2017
Genome-Wide Profiling Reveals That Herbal Medicine Jinfukang-Induced Polyadenylation Alteration Is Involved in Anti-Lung Cancer Activity.
Article in Evidence-based complementary and alternative medicine : eCAM, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 11 citations in OpenAlex.
- Impact of COL6A4P2 gene polymorphisms on the risk of lung cancer: A case-control study.PloS one · 2021Article
- Anticancer Effects of Herbal Medicine Compounds and Novel Formulations: a Literature Review.Journal of gastrointestinal cancer · 2020Review
- Article
- Herbal formula Yangyinjiedu induces lung cancer cell apoptosis via activation of early growth response 1.Journal of cellular and molecular medicine · 2019Article
- Maintenance Chemotherapy With Chinese Herb Medicine Formulas vs. With Placebo in Patients With Advanced Non-small Cell Lung Cancer After First-Line Chemotherapy: A Multicenter, Randomized, Double-Blind Trial.Frontiers in pharmacology · 2018Article
- Induction of Senescence in Lung Cancer Cells by Qidongning Formula via the Transcription Factor EGR1.Integrative cancer therapiesArticle
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
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Abstract
Alternative polyadenylation (APA) plays an important role in regulation of genes expression and is involved in many biological processes. As eukaryotic cells receive a variety of external signals, genes produce diverse transcriptional isoforms and exhibit different translation efficiency. The traditional Chinese medicine (TCM) Jinfukang (JFK) has been effectively used for lung cancer treatment. In this study, we investigated whether JFK exerts its antitumor effect by modulating APA patterns in lung cancer cells. We performed a genome-wide APA site profiling analysis in JFK treated lung cancer cells A549 with 3T-seq approach that we reported previously. Comparing with those in untreated A549, in JFK treated A549 we observed APA-mediated 3' UTRs alterations in 310 genes including 77 genes with shortened 3' UTRs. In particular, we identified
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Registered trials
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