ReviewFrontiers in neurology2017
Temporal Discrimination: Mechanisms and Relevance to Adult-Onset Dystonia.
Review in Frontiers in neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- A Systematic Review of Cognition in Cervical Dystonia.Neuropsychology review · 2024Pooled it
- Mind the gap: the temporal discrimination threshold of tactile sensation from implanted peripheral nerve stimulation.Journal of neuroengineering and rehabilitation · 2026Trial
- Regulation of Somatosensory Temporal Discrimination Threshold Through Motor Training: An EEG and Kinematics Study.CNS neuroscience & therapeutics · 2025Trial
- Cerebellar Transcranial Direct Current Stimulation Does Not Alter Somatosensory Temporal Discrimination Threshold.Cerebellum (London, England) · 2022Trial
- Cereblon-related mild intellectual disability disrupts response inhibition and uniformity of group-individual strategies.Frontiers in neuroscience · 2026Article
- Temporal discrimination at the neck region is associated with severity of cervical dystonia.Scientific reports · 2025Article
- Do Hormonal Fluctuations in Healthy Women Influence the Somatosensory Temporal Discrimination Threshold?Brain and behavior · 2025Article
- Multivariate Pattern Analysis of fMRI Reveals Striato-Cortical Network Changes in Myoclonus-Dystonia.European journal of neurology · 2025Article
- Contribution of testosterone and estradiol in sexual dimorphism of early-onset Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- Article
- Video-based diagnosis support system for pianists with Musician's dystonia.Frontiers in neurology · 2024Article
- Cell-specific Dyt1 ∆GAG knock-in to basal ganglia and cerebellum reveal differential effects on motor behavior and sensorimotor network function.Experimental neurology · 2023Article
- Investigating the Effects of a Focal Muscle Vibration Protocol on Sensorimotor Integration in Healthy Subjects.Brain sciences · 2023Article
- Sensory processing in the auditory and olfactory domains is normal in laryngeal dystonia.Journal of neurology · 2023Article
- Impact of Depression on Cognitive Function and Disease Severity in Idiopathic Cervical Dystonia Patients: One-Center Data in Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2022Article
- Characterizing the temporal discrimination threshold in musician's dystonia.Scientific reports · 2022Article
- Functional Neural Networks in Writer's Cramp as Determined by Graph-Theoretical Analysis.Frontiers in neurology · 2021Article
- Dystonia Management: What to Expect From the Future? The Perspectives of Patients and Clinicians Within DystoniaNet Europe.Frontiers in neurology · 2021Review
- Abnormal effective connectivity in the sensory network in writer's cramp.NeuroImage. Clinical · 2021Article
- Does the network model fits neurophysiological abnormalities in blepharospasm?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Temporal discrimination is the ability to determine that two sequential sensory stimuli are separated in time. For any individual, the temporal discrimination threshold (TDT) is the minimum interval at which paired sequential stimuli are perceived as being asynchronous; this can be assessed, with high test-retest and inter-rater reliability, using a simple psychophysical test. Temporal discrimination is disordered in a number of basal ganglia diseases including adult-onset dystonia, of which the two most common phenotypes are cervical dystonia and blepharospasm. The causes of adult-onset focal dystonia are unknown; genetic, epigenetic, and environmental factors are relevant. Abnormal TDTs in adult-onset dystonia are associated with structural and neurophysiological changes considered to reflect defective inhibitory interneuronal processing within a network which includes the superior colliculus, basal ganglia, and primary somatosensory cortex. It is hypothesized that abnormal temporal discrimination is a mediational endophenotype and, when present in unaffected relatives of patients with adult-onset dystonia, indicates non-manifesting gene carriage. Using the mediational endophenotype concept, etiological factors in adult-onset dystonia may be examined including (i) the role of environmental exposures in disease penetrance and expression; (ii) sexual dimorphism in sex ratios at age of onset; (iii) the pathogenesis of non-motor symptoms of adult-onset dystonia; and (iv) subcortical mechanisms in disease pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.