Evidence map›Paper›PMID 29234200›Full record

ReviewJournal of clinical and experimental hepatology2017

Nutrition and Muscle in Cirrhosis.

Anil C Anand

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of clinical and experimental hepatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 2 pooled it
8.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 2 syntheses or guidelines pooled it, 166 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Effect of long-term aggressive nutrition therapy on survival in patients with alcohol-related cirrhosis: A randomized controlled trial.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2022
    Trial
  4. Trial
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  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
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  14. [Metabolic associated fatty liver disease induced cirrhosis: epidemiology, risk factors, and new strategies for precise prevention and control].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2025
    Review
  15. Review
  16. Article
  17. Observational
  18. Article
  19. Article
  20. Review

28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Anil C AnandIndraprastha Apollo Hospital, New Delhi, India.
Indraprastha Apollo Hospitals · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As the cirrhosis progresses, development of complication like ascites, hepatic encephalopathy, variceal bleeding, kidney dysfunction, and hepatocellular carcinoma signify increasing risk of short term mortality. Malnutrition and muscle wasting (sarcopenia) is yet other complications that negatively impact survival, quality of life, and response to stressors, such as infection and surgery in patients with cirrhosis. Conventionally, these are not routinely looked for, because nutritional assessment can be a difficult especially if there is associated fluid retention and/or obesity. Patients with cirrhosis may have a combination of loss of skeletal muscle and gain of adipose tissue, culminating in the condition of "sarcopenic obesity." Sarcopenia in cirrhotic patients has been associated with increased mortality, sepsis complications, hyperammonemia, overt hepatic encephalopathy, and increased length of stay after liver transplantation. Assessment of muscles with cross-sectional imaging studies has become an attractive index of nutritional status evaluation in cirrhosis, as sarcopenia, the major component of malnutrition, is primarily responsible for the adverse clinical consequences seen in patients with liver disease. Cirrhosis is a state of accelerated starvation, with increased gluconeogenesis that requires amino acid diversion from other metabolic functions. Protein homeostasis is disturbed in cirrhosis due to several factors such as hyperammonemia, hormonal, and cytokine abnormalities, physical inactivity and direct effects of ethanol and its metabolites. New approaches to manage sarcopenia are being evolved. Branched chain amino acid supplementation, Myostatin inhibitors, and mitochondrial protective agents are currently in various stages of evaluation in preclinical studies to prevent and reverse sarcopenia, in cirrhosis.

Indexed as

aKG, alfa keto glutarateAkt/PKB, serine/threonine-specific protein kinase BAMPK, 5′ adenosine monophosphate-activated protein kinaseASPEN, American Society of Parenteral and Enteral NutritionATP, adenosine triphosphateBIA, bio-electric impedance analysisBMC, bone mineral contentBMI, body mass indexcirrhosisCT, computed tomographyDDLT, deceased donor liver transplantationDRM, disease-related malnutritionDXA, dual X-ray absorptiometryESPEN, European Society of Parenteral and Enteral NutritionFFI, Fried Frailty IndexFFM, fat free massFFMI, fat free mass indexFM, fat massHE, hepatic encephalopathyLDLT, living donor liver transplantLST, lean soft tissueMAC, mid arm circumferenceMAMC, mid arm muscle circumferenceMELD, model for end-stage liver diseaseMNA, Mini Nutritional AssessmentMRI, magnetic resonance imagingmTORC1, mammalian target of rapamycin complex 1NASH, non-alcoholic steatohepatitisnutritionPCM, protein-calorie nalnutrition(PG) SGA, patient-generated SGAREE, resting energy expenditureRQ, respiratory quotient (or RQ or respiratory coefficient)SGA, Subjective Global AssessmentSMI, Skeletal Muscle IndexSPPB, Short Physical Performance BatteryTIPS, trans jugular intrahepatic portocaval shuntsTNF, tumour necrosis factorTSF, triceps skin fild thicknessWHO, World Health OrganisationYPA, total psoas area

Identifiers

PMID29234200
PMCPMC5719462
OpenAlexW2767726137

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.