ArticleScientific reports2017
Role of ATP Hydrolysis in Cyanobacterial Circadian Oscillator.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- Role of the reaction-structure coupling in temperature compensation of the KaiABC circadian rhythm.PLoS computational biology · 2022Article
- Dimer dissociation is a key energetic event in the fold-switch pathway of KaiB.Biophysical journal · 2022Article
- Mechanism of autonomous synchronization of the circadian KaiABC rhythm.Scientific reports · 2021Article
- For Whom the Clock Ticks: Clinical Chronobiology for Infectious Diseases.Frontiers in immunology · 2020Review
- Conformational rearrangements of the C1 ring in KaiC measure the timing of assembly with KaiB.Scientific reports · 2018Article
- Single-molecular and ensemble-level oscillations of cyanobacterial circadian clock.Biophysics and physicobiology · 2018Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A cyanobacterial protein KaiC shows a stable oscillation in its phosphorylation level with approximately one day period when three proteins, KaiA, KaiB, and KaiC, are incubated in the presence of ATP in vitro. During this oscillation, KaiC hydrolyzes more ATP molecules than required for phosphorylation. Here, in this report, a theoretical model of the KaiABC oscillator is developed to elucidate the role of this ATP consumption by assuming multifold feedback relations among reactions and structural transition in each KaiC molecule and the structure-dependent binding reactions among Kai proteins. Results of numerical simulation showed that ATP hydrolysis is a driving mechanism of the phosphorylation oscillation in the present model, and that the frequency of ATP hydrolysis in individual KaiC molecules is correlated to the frequency of oscillation in the ensemble of many Kai molecules, which indicates that the coherent oscillation is generated through the coupled microscopic intramolecular and ensemble-level many-molecular regulations.
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