ArticleScientific reports2017
The glutamic residue at position 402 in the C-terminus of Newcastle disease virus nucleoprotein is critical for the virus.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The multifaceted interactions between Newcastle disease virus proteins and host proteins: a systematic review.Virulence · 2024Pooled it
- Recent advancements in the diverse roles of polymerase-associated proteins in the replication and pathogenesis of Newcastle disease virus.Veterinary research · 2025Review
- The NP protein of Newcastle disease virus dictates its oncolytic activity by regulating viral mRNA translation efficiency.PLoS pathogens · 2024Article
- Newcastle disease virus: the past and current situation in Indonesia.Journal of veterinary science · 2024Review
- Methyltransferase K-D-K-E motif influences the intercellular transmission of Newcastle disease virus.Virulence · 2023Article
- Mutation of Basic Residues R283, R286, and K288 in the Matrix Protein of Newcastle Disease Virus Attenuates Viral Replication and Pathogenicity.International journal of molecular sciences · 2023Article
- Review detection of Newcastle disease virus.Frontiers in veterinary science · 2022Review
- Mutations in the Methyltransferase Motifs of L Protein Attenuate Newcastle Disease Virus by Regulating Viral Translation and Cell-to-Cell Spread.Microbiology spectrum · 2021Article
- Mechanisms and consequences of Newcastle disease virus W protein subcellular localization in the nucleus or mitochondria.Journal of virology · 2021Article
- Article
- Chicken bromodomain-containing protein 2 interacts with the Newcastle disease virus matrix protein and promotes viral replication.Veterinary research · 2020Article
- Host CARD11 Inhibits Newcastle Disease Virus Replication by Suppressing Viral Polymerase Activity in Neurons.Journal of virology · 2019Article
- Nuclear localization of Newcastle disease virus matrix protein promotes virus replication by affecting viral RNA synthesis and transcription and inhibiting host cell transcription.Veterinary research · 2019Article
- The phylogenomics of evolving virus virulence.Nature reviews. Genetics · 2018Review
- Genetic Changes in Pigeon Paramyxovirus Type-1 Induced by Serial Passages in Chickens and Microscopic Lesions Caused by the Virus in Various Avian Hosts.Journal of veterinary research · 2018Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nucleocapsid proteins (NPs) of Newcastle disease virus (NDV) and other paramyxoviruses play an important functional role during genomic RNA replication. Our previous study showed that the NP-encoding gene significantly influenced viral replication. Here, we investigated the roles of certain amino acid residues in the NP C-terminus in viral replication and virulence. Results showed that the glutamic acid residue at position 402 (E402) in the C-terminus of the NP is critical for RNA synthesis in the NDV mini-genome system. Mutation of E402 resulted in larger viral plaques that appeared more quickly, and increased the virulence of NDV. Further study indicated that the mutant virus had increased RNA levels during the early stages of virus infection, but that RNA replication was inhibited at later time points. These findings increase our knowledge of viral replication and contribute to a more comprehensive understanding of the virulence factors associated with NDV.
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