Evidence map›Paper›PMID 29234109›Full record

ArticleScientific reports2017

The AP-1 transcription factor JunB is required for Th17 cell differentiation.

Soh Yamazaki, Yoshihiko Tanaka, Hiromitsu Araki, Akira Kohda, Fumiyuki Sanematsu, Tomoko Arasaki, Xuefeng Duan, Fumihito Miura, Takaharu Katagiri, Ryodai Shindo and 5 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 72 citations in OpenAlex.

  1. Article
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  5. Article
  6. Th17 cell pathogenicity in autoimmune disease.Experimental & molecular medicine · 2025
    Review
  7. Article
  8. Article
  9. Article
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  11. Article
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  13. Review
  14. Restriction of innate Tγδ17 cell plasticity by an AP-1 regulatory axis.bioRxiv : the preprint server for biology · 2024
    Article
  15. Article
  16. Class IIa HDAC4 and HDAC7 cooperatively regulate gene transcription in Th17 cell differentiation.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Soh YamazakiDepartment of Biochemistry, Kyushu University Graduate School of Medical Sciences, Fukuoka, 812-8582, Japan.
Yoshihiko TanakaDivision of Immunogenetics, Department of Immunobiology of Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka, 812-8582, Japan.
Hiromitsu ArakiDepartment of Biochemistry, Kyushu University Graduate School of Medical Sciences, Fukuoka, 812-8582, Japan.
Akira KohdaDepartment of Biochemistry, Kyushu University Graduate School of Medical Sciences, Fukuoka, 812-8582, Japan.
Fumiyuki SanematsuDivision of Immunogenetics, Department of Immunobiology of Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka, 812-8582, Japan.
Tomoko ArasakiAging Neuroscience Research Team, Tokyo Metropolitan Institute of Gerontology, Tokyo, 173-0015, Japan.
Xuefeng DuanDivision of Immunogenetics, Department of Immunobiology of Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka, 812-8582, Japan.
Fumihito MiuraDepartment of Biochemistry, Kyushu University Graduate School of Medical Sciences, Fukuoka, 812-8582, Japan.
Takaharu KatagiriDepartment of Biochemistry, Toho University School of Medicine, Tokyo, 143-8540, Japan.
Ryodai ShindoDepartment of Biochemistry, Toho University School of Medicine, Tokyo, 143-8540, Japan.
Hiroyasu NakanoDepartment of Biochemistry, Toho University School of Medicine, Tokyo, 143-8540, Japan.ORCID 0000-0003-4843-1427
Takashi ItoDepartment of Biochemistry, Kyushu University Graduate School of Medical Sciences, Fukuoka, 812-8582, Japan.
Yoshinori FukuiDivision of Immunogenetics, Department of Immunobiology of Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka, 812-8582, Japan.
Shogo EndoAging Neuroscience Research Team, Tokyo Metropolitan Institute of Gerontology, Tokyo, 173-0015, Japan.
Hideki SumimotoDepartment of Biochemistry, Kyushu University Graduate School of Medical Sciences, Fukuoka, 812-8582, Japan. hsumi@med.kyushu-u.ac.jp.
Kyushu University · JPToho University · JPTokyo Metropolitan Institute of Gerontology · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interleukin (IL)-17-producing T helper (Th17) cells are crucial for host defense against extracellular microbes and pathogenesis of autoimmune diseases. Here we show that the AP-1 transcription factor JunB is required for Th17 cell development. Junb-deficient CD4

Indexed as

3T3 CellsAnimalsBasic-Leucine Zipper Transcription FactorsCell DifferentiationCell Line, TumorEncephalomyelitis, Autoimmune, ExperimentalHEK293 CellsHomeodomain ProteinsHumansMiceMice, Inbred C57BLMice, TransgenicNuclear Receptor Subfamily 1, Group F, Member 1Nuclear Receptor Subfamily 1, Group F, Member 3Proto-Oncogene Proteins c-junPsoriasisBasic-Leucine Zipper Transcription FactorsBatf protein, mouseHomeodomain ProteinsJunB protein, mousejunD protein, mouseMeox2 protein, mouseNuclear Receptor Subfamily 1, Group F, Member 1Nuclear Receptor Subfamily 1, Group F, Member 3Proto-Oncogene Proteins c-junRora protein, mouseRorc protein, mouseTranscription Factors

Identifiers

PMID29234109
PMCPMC5727176
OpenAlexW2774242593

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.