Evidence map›Paper›PMID 29234107›Full record

ArticleScientific reports2017

Bulky Lesion Bypass Requires Dpo4 Binding in Distinct Conformations.

Pramodha S Liyanage, Alice R Walker, Alfonso Brenlla, G Andrés Cisneros, Louis J Romano, David Rueda

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Pramodha S LiyanageDepartment of Chemistry, Wayne State University, Detroit, MI, 48202, USA.
Alice R WalkerDepartment of Chemistry, University of North Texas, Denton, TX, 76201, USA.ORCID 0000-0002-8617-3425
Alfonso BrenllaDepartment of Chemistry, Wayne State University, Detroit, MI, 48202, USA.
G Andrés CisnerosDepartment of Chemistry, University of North Texas, Denton, TX, 76201, USA.
Louis J RomanoDepartment of Chemistry, Wayne State University, Detroit, MI, 48202, USA. ljr@chem.wayne.edu.
David RuedaMolecular Virology, Department of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK. david.rueda@imperial.ac.uk.ORCID 0000-0003-4657-6323

Funding

BIOLOGICAL CONSEQUENCES OF SITE-SPECIFIC DAMAGE TO DNAR01CA040605 · NCI · WAYNE STATE UNIVERSITY · PI ROMANO, LOUIS J · 1986 to 2014
$2.9M
Medical Research Council MC_UP_1102/5NCI NIH HHS R01 CA040605
6 · The paper itself

Abstract

Translesion DNA synthesis is an essential process that helps resume DNA replication at forks stalled near bulky adducts on the DNA. Benzo[a]pyrene (B[a]P) is a polycyclic aromatic hydrocarbon (PAH) that can be metabolically activated to benzo[a]pyrene diol epoxide (BPDE), which then can react with DNA to form carcinogenic DNA adducts. Here, we have used single-molecule florescence resonance energy transfer (smFRET) experiments, classical molecular dynamics simulations, and nucleotide incorporation assays to investigate the mechanism by which the model Y-family polymerase, Dpo4, bypasses a (+)-cis-B[a]P-N

Indexed as

DNA RepairMolecular Dynamics SimulationBenzo(a)pyreneDNA AdductsDNA-Directed DNA PolymeraseDNA Repair EnzymesDNA ReplicationSulfolobus solfataricusBenzo(a)pyrenebenzo(a)pyrene-DNA adductDNA AdductsDNA-Directed DNA PolymeraseDNA Repair Enzymes

Identifiers

PMID29234107
PMCPMC5727293

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.