Evidence map›Paper›PMID 29234083›Full record

ArticleScientific reports2017

Nod2 is required for the early innate immune clearance of Acinetobacter baumannii from the lungs.

Sandeep D Kale, Neha Dikshit, Pankaj Kumar, Vanniarajan Balamuralidhar, Hanif Javanmard Khameneh, Najib Bin Abdul Malik, Tse Hsien Koh, Gladys Gek Yen Tan, Thuan Tong Tan, Alessandra Mortellaro and 1 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. IntracellularProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Virulence Factors and Pathogenicity Mechanisms ofAntibiotics (Basel, Switzerland) · 2023
    Review
  7. mBio · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. The Role of Innate Immunity in Pulmonary Infections.BioMed research international · 2021
    Review
  14. Host Innate Immune Responses toFrontiers in cellular and infection microbiology · 2020
    Review
  15. Article
  16. Innate Immune Responses toJournal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2019
    Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Sandeep D KaleProgram in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, 169857, Singapore.
Neha DikshitProgram in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, 169857, Singapore.
Pankaj KumarProgram in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, 169857, Singapore.
Vanniarajan BalamuralidharProgram in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, 169857, Singapore.
Hanif Javanmard KhamenehSingapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, 138648, Singapore.
Najib Bin Abdul MalikProgram in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, 169857, Singapore.
Tse Hsien KohDepartment of Microbiology, Division of Pathology, Singapore General Hospital, Singapore, Singapore.
Gladys Gek Yen TanDSO National Laboratories, Singapore, Singapore.
Thuan Tong TanDepartment of Infectious Diseases, Singapore General Hospital, Singapore, Singapore.
Alessandra MortellaroSingapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, 138648, Singapore.ORCID 0000-0003-1744-2430
Bindu SukumaranProgram in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, 169857, Singapore. bindu.sukumaran@duke-nus.edu.sg.
Duke-NUS Medical School · SGAgency for Science, Technology and Research · SGSingapore General Hospital · SGDSO National Laboratories · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acinetobacter baumannii (A. baumannii) is a significant cause of severe nosocomial pneumonia in immunocompromised individuals world-wide. With limited treatment options available, a better understanding of host immnity to A. baumannii infection is critical to devise alternative control strategies. Our previous study has identified that intracellular Nod1/Nod2 signaling pathway is required for the immune control of A. baumannii in airway epithelial cells in vitro. In the current study, using Nod2

Indexed as

Acetylmuramyl-Alanyl-IsoglutamineAcinetobacter baumanniiAcinetobacter InfectionsAnimalsAnti-Infective AgentsFemaleImmunity, InnateLungMice, Inbred C57BLMice, KnockoutNod2 Signaling Adaptor ProteinReactive Nitrogen SpeciesReactive Oxygen SpeciesAcetylmuramyl-Alanyl-IsoglutamineAnti-Infective AgentsNod2 protein, mouseNod2 Signaling Adaptor ProteinReactive Nitrogen SpeciesReactive Oxygen Species

Identifiers

PMID29234083
PMCPMC5727160
OpenAlexW2771918524

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.