ArticleNature communications2017
Evolution of a flipped pathway creates metabolic innovation in tomato trichomes through BAHD enzyme promiscuity.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 68 citations in OpenAlex.
- Structurally diverse acylsugars on wild tomatillo fruit surfaces.Horticulture research · 2026Article
- A metabolic complex of acyltransferase enzymes involved in tomato acylsugar biosynthesis.Journal of experimental botany · 2026Article
- The plasma membrane ABC transporter Sl-ABCB5 mediates acylsugar secretion from tomato trichomes to confer insect resistance.Plant communications · 2026Article
- Functional diversification of WRINKLED3 integrates fatty acid metabolism with insecticidal acylsugar production in Solanaceae species.Nature communications · 2026Article
- Trading acyls and swapping sugars: metabolic innovations in Solanum trichomes.Plant physiology · 2024Article
- Tomato root specialized metabolites evolved through gene duplication and regulatory divergence within a biosynthetic gene cluster.Science advances · 2024Article
- Trading acyls and swapping sugars: metabolic innovations inbioRxiv : the preprint server for biology · 2024Article
- Phylogenomic analyses across land plants reveals motifs and coexpression patterns useful for functional prediction in the BAHD acyltransferase family.Frontiers in plant science · 2023Article
- Natural variation meets synthetic biology: Promiscuous trichome-expressed acyltransferases from Nicotiana.Plant physiology · 2022Article
- Fruity, sticky, stinky, spicy, bitter, addictive, and deadly: evolutionary signatures of metabolic complexity in the Solanaceae.Natural product reports · 2022Review
- Using interdisciplinary, phylogeny-guided approaches to understand the evolution of plant metabolism.Plant molecular biology · 2022Review
- Identification of BAHD acyltransferases associated with acylinositol biosynthesis inPlant direct · 2022Article
- It happened again: Convergent evolution of acylglucose specialized metabolism in black nightshade and wild tomato.Science advances · 2021Article
- Migration through a Major Andean Ecogeographic Disruption as a Driver of Genetic and Phenotypic Diversity in a Wild Tomato Species.Molecular biology and evolution · 2021Article
- Natural variation in wild tomato trichomes; selecting metabolites that contribute to insect resistance using a random forest approach.BMC plant biology · 2021Article
- An Integrated Analytical Approach Reveals Trichome Acylsugar Metabolite Diversity in the Wild TomatoMetabolites · 2020Article
- Two BAHD Acyltransferases Catalyze the Last Step in the Shikonin/Alkannin Biosynthetic Pathway.Plant physiology · 2020Article
- Article
- Specialized Metabolism in a Nonmodel Nightshade: Trichome Acylinositol Biosynthesis.Plant physiology · 2020Article
- Candidate Gene Networks for Acylsugar Metabolism and Plant Defense in Wild TomatoThe Plant cell · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plants produce hundreds of thousands of structurally diverse specialized metabolites via multistep biosynthetic networks, including compounds of ecological and therapeutic importance. These pathways are restricted to specific plant groups, and are excellent systems for understanding metabolic evolution. Tomato and other plants in the nightshade family synthesize protective acylated sugars in the tip cells of glandular trichomes on stems and leaves. We describe a metabolic innovation in wild tomato species that contributes to acylsucrose structural diversity. A small number of amino acid changes in two acylsucrose acyltransferases alter their acyl acceptor preferences, resulting in reversal of their order of reaction and increased product diversity. This study demonstrates how small numbers of amino acid changes in multiple pathway enzymes can lead to diversification of specialized metabolites in plants. It also highlights the power of a combined genetic, genomic and in vitro biochemical approach to identify the evolutionary mechanisms leading to metabolic novelty.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.